Mianserin updated on 07-01-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11803
R43407		 Kjaersgaard, 2013 Spontaneous abortion (before 22 weeks of gestation) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.25 [0.74;2.11] -/-   -/983,258 - -
ref
S11759
R43208		 Yaris, 2005 Spontaneous abortions during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 6.64 [0.67;65.57] C 1/5   9/248 10 5
ref
Total 2 studies 1.96 [0.46;8.33] 10 5
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kjaersgaard, 2013Kjaersgaard, 2013 1.25[0.74; 2.11]--73%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Yaris, 2005Yaris, 2005 6.64[0.67; 65.57]10527%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Total (2 studies) I2 = 48% 1.96[0.46; 8.33]1050.520.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.96[0.46; 8.33]10548%NAKjaersgaard, 2013 Yaris, 2005 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.96[0.46; 8.33]10548%NAKjaersgaard, 2013 Yaris, 2005 2 Tags Adjustment   - No  - No 1.96[0.46; 8.33]10548%NAKjaersgaard, 2013 Yaris, 2005 2 Monotherapy   - no or not specified  - no or not specified 1.96[0.46; 8.33]10548%NAKjaersgaard, 2013 Yaris, 2005 2 All studiesAll studies 1.96[0.46; 8.33]10548%NAKjaersgaard, 2013 Yaris, 2005 20.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.96[0.46; 8.33]10548%NAKjaersgaard, 2013 Yaris, 2005 20.510.01.0