Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) updated on 07-01-2025

Macrosomia (> 4000g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11693
R42997		 Reis - SNRI (Controls exposed to TCA), 2010 High birthweight (>4500 g) 2nd and/or 3rd trimester population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No Monotherapy: SNRI only 1.26 [0.66;2.38] C
excluded (control group) 		18/538   21/784 39 538
ref
S11694
R43009		 Reis - SNRI (Controls unexposed, NOS), 2010 High birthweight (>4500 g) 2nd and/or 3rd trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: SNRI only 0.80 [0.53;1.38] 18/538   46,050/1,062,190 46,068 538
ref
Total 1 studies 0.80 [0.50;1.29] 46,068 538
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Reis - SNRI (Controls unexposed, NOS), 2010Reis - SNRI, 2010 1 0.80[0.53; 1.38]46,0685380%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.80[0.50; 1.29]46,068538 -NAReis - SNRI (Controls unexposed, NOS), 2010 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.80[0.50; 1.29]46,068538 -NAReis - SNRI (Controls unexposed, NOS), 2010 1 Tags Adjustment   - Yes  - Yes 0.80[0.50; 1.29]46,068538 -NAReis - SNRI (Controls unexposed, NOS), 2010 1 Monotherapy   - SNRI only  - SNRI only 0.80[0.50; 1.29]46,068538 -NAReis - SNRI (Controls unexposed, NOS), 2010 1 All studiesAll studies 0.80[0.50; 1.29]46,068538 -NAReis - SNRI (Controls unexposed, NOS), 2010 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 11693

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.80[0.50; 1.29]46,068538 -NAReis - SNRI (Controls unexposed, NOS), 2010 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.26[0.66; 2.38]39538 -NAReis - SNRI (Controls exposed to TCA), 2010 10.510.01.0