Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) updated on 07-01-2025

Low birth weight (< 2500g)

id	Study   Auto Lee (Controls exposed to TCAs), 2025Lee (Controls unexposed, general pop), 2025Benevent - SNRI, 2023Reis - SNRI (Controls exposed to TCA), 2010Reis - SNRI (Controls unexposed, NOS), 2010Calderon-Margalit - Venlafaxine, 2009	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimesterPaternal exp. genotoxic window only (0–3 months preconception)Paternal exposure: epigenetic window only (3–xxx months preconception)Paternal exposure: genotoxic/epigenetic window (0–xxx months preconception)Paternal exposure: other window	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S18440 R78233	Lee (Controls exposed to TCAs), 2025	Low birth weight (birth weight <2500 g)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: No Monotherapy: SNRI only	1.47 [0.74;2.93] C excluded (control group)	11/71   68/613	79	71		ref
S18441 R78254	Lee (Controls unexposed, general pop), 2025	Low birth weight (birth weight <2500 g)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: SNRI only	1.41 [0.74;2.70]	11/71   31,347/463,440	31,358	71		ref
S15171 R62276	Benevent - SNRI, 2023	Low birth weight	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No Monotherapy: SNRI only	1.40 [0.84;2.34] C	16/215   7,763/143,301	7,779	215		ref
S11693 R42996	Reis - SNRI (Controls exposed to TCA), 2010	Low birthweight (<2500 g)	2nd and/or 3rd trimester	population based cohort retrospective	exposed to other treatment, sick excluded	Adjustment: No Monotherapy: SNRI only	1.45 [0.90;2.32] C excluded (control group)	36/538   37/784	73	538		ref
S11694 R43008	Reis - SNRI (Controls unexposed, NOS), 2010	Low birthweight (<2500 g)	2nd and/or 3rd trimester	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: SNRI only	1.87 [1.33;2.64]	36/538   37,105/1,062,190	37,141	538		ref
S13352 R51469	Calderon-Margalit - Venlafaxine, 2009	Low Birth-Weight (< 2500gr)	during pregnancy (anytime or not specified)	prospective cohort	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: no or not specified	2.14 [0.35;13.30]	-/9   -/2,493	-	9		ref
					Total	4 studies	1.67 [1.29;2.16]		76,278	833
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 11693, 18440

Umbrella review (other published meta-analyses)