Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) updated on 07-01-2025

Therapeutic terminations of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11691
R42991		 Kieler - Venlafaxine, 2015 Termination of pregnancy for Fetal anomaly during pregnancy (anytime or not specified) nested case control unexposed (general population or NOS) Adjustment: Yes Matched Monotherapy: SNRI only 1.20 [0.50;2.70] -/-   0/- - -
ref
S11755
R43203		 Einarson - Venlafaxine, 2001 Therapeutic abortion at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 3.62 [0.74;17.73] C 7/150   2/150 9 150
ref
Total 2 studies 1.68 [0.62;4.57] 9 150
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kieler - Venlafaxine, 2015Kieler - Venlafaxine, 2015 1.20[0.50; 2.70]--69%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Einarson - Venlafaxine, 2001Einarson - Venlafaxine, 2001 3.62[0.74; 17.73]915031%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 31% 1.68[0.62; 4.57]91500.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.62[0.74; 17.73]9150 -NAEinarson - Venlafaxine, 2001 1 case control studiescase control studies 1.20[0.52; 2.79]-- -NAKieler - Venlafaxine, 2015 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.68[0.62; 4.57]915031%NAKieler - Venlafaxine, 2015 Einarson - Venlafaxine, 2001 2 Tags Adjustment   - No  - No 3.62[0.74; 17.73]9150 -NAEinarson - Venlafaxine, 2001 1   - Yes  - Yes 1.20[0.52; 2.79]-- -NAKieler - Venlafaxine, 2015 1 MatchedMatched 1.20[0.52; 2.79]-- -NAKieler - Venlafaxine, 2015 1 Monotherapy   - no or not specified  - no or not specified 3.62[0.74; 17.73]9150 -NAEinarson - Venlafaxine, 2001 1   - SNRI only  - SNRI only 1.20[0.52; 2.79]-- -NAKieler - Venlafaxine, 2015 1 All studiesAll studies 1.68[0.62; 4.57]915031%NAKieler - Venlafaxine, 2015 Einarson - Venlafaxine, 2001 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.68[0.62; 4.57]915031%NAKieler - Venlafaxine, 2015 Einarson - Venlafaxine, 2001 20.510.01.0