Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) - Medication and Pregnancy KB

Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) updated on 07-01-2025

Eye defects

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S15171 R62280	Benevent - SNRI, 2023	Eye malformations	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No Monotherapy: SNRI only	2.45 [0.15;39.56] ^C	0/314 95/146,855	95	314		ref
S11684 R42944	Ankarfeldt a - Duloxetine (Controls unexposed, NOS), 2021	Eye malformations	1st trimester	population based cohort retrospective	unexposed (general population or NOS) excluded	Adjustment: Yes Monotherapy: no or not specified	1.25 [0.46;3.41] excluded (control group)	5/1,438 16/5,751	21	1,438		ref
S11685 R42960	Ankarfeldt a - Duloxetine (Controls unexposed, sick), 2021	Eye malformations	1st trimester	population based cohort retrospective	unexposed, sick	Adjustment: Yes Monotherapy: no or not specified Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy)	0.63 [0.20;1.91]	5/1,434 8/1,435	13	1,434		ref
S11745 R43130	Huybrechts - Duloxetine (Controls unexposed, NOS), 2020	Eye Anomalies	1st trimester	retrospective cohort (claims database)	unexposed (general population or NOS) excluded	Adjustment: Yes Monotherapy: no or not specified	0.98 [0.14;7.01] excluded (control group)	-/2,532 -/-	-	2,532		ref
S11746 R43144	Huybrechts - Duloxetine (Controls unexposed, sick), 2020	Eye Anomalies	1st trimester	retrospective cohort (claims database)	unexposed, sick	Adjustment: Yes Monotherapy: no or not specified Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy)	1.00 [0.06;17.34]	-/2,532 -/2,456	-	2,532		ref
					Total	3 studies	0.79 [0.30;2.10]		108	4,280
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick; 2: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 11745, 11684