Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) - Medication and Pregnancy KB

Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) updated on 07-01-2025

Severe congenital heart defect

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S11832 R43439	Kolding - Venlafaxine (Controls unexposed, disease free), 2021	Severe cardiac malformations (cardiac malformations that end in miscarriage, termination, stillbirth, postnatal death or cardiac surgery <1 year of birth)	1st trimester	population based cohort retrospective	unexposed, disease free excluded	Adjustment: Yes Monotherapy: no or not specified	2.13 [0.89;5.13] excluded (control group)	5/847 915/346,227	920	847		ref
S11833 R43442	Kolding - Venlafaxine (Controls unexposed, sick), 2021	Severe cardiac malformations (cardiac malformations that end in miscarriage, termination, stillbirth, postnatal death or cardiac surgery <1 year of birth)	1st trimester	population based cohort retrospective	unexposed, sick	Adjustment: No Monotherapy: no or not specified Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy)	1.78 [0.67;4.70]	5/847 21/6,305	26	847		ref
					Total	1 studies	1.78 [0.67;4.71]		26	847
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 11832