Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) updated on 07-01-2025

Other congenital malformations (Q80 to Q99)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11745
R43139		 Huybrechts - Duloxetine (Controls unexposed, NOS), 2020 Other malformations (ICD9 757.xx; 759.xx) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) excluded Adjustment: Yes Monotherapy: no or not specified 2.98 [1.41;6.29]
excluded (control group) 		-/2,532   -/- - 2,532
ref
S11746
R43153		 Huybrechts - Duloxetine (Controls unexposed, sick), 2020 Other malformations (ICD9 757.xx; 759.xx) 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes Monotherapy: no or not specified Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 1.33 [0.41;4.28] -/2,532   -/2,456 - 2,532
ref
Total 1 studies 1.33 [0.41;4.30] 0 2,532
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts - Duloxetine (Controls unexposed, sick), 2020Huybrechts - Duloxetine, 2020 1 1.33[0.41; 4.28]-2,5320%ROB confusion: moderateROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: low0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.33[0.41; 4.30]-2,532 -NAHuybrechts - Duloxetine (Controls unexposed, sick), 2020 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.33[0.41; 4.30]-2,532 -NAHuybrechts - Duloxetine (Controls unexposed, sick), 2020 1 Tags Adjustment   - Yes  - Yes 1.33[0.41; 4.30]-2,532 -NAHuybrechts - Duloxetine (Controls unexposed, sick), 2020 1 Monotherapy   - no or not specified  - no or not specified 1.33[0.41; 4.30]-2,532 -NAHuybrechts - Duloxetine (Controls unexposed, sick), 2020 1 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 1.33[0.41; 4.30]-2,532 -NAHuybrechts - Duloxetine (Controls unexposed, sick), 2020 1 All studiesAll studies 1.33[0.41; 4.30]-2,532 -NAHuybrechts - Duloxetine (Controls unexposed, sick), 2020 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 11745

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.98[1.41; 6.29]-2,532 -NAHuybrechts - Duloxetine (Controls unexposed, NOS), 2020 1 unexposed, sick controlsunexposed, sick controls 1.33[0.41; 4.30]-2,532 -NAHuybrechts - Duloxetine (Controls unexposed, sick), 2020 10.510.01.0