Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) updated on 07-01-2025

Craniosynostosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11771
R43270		 Anderson - SNRI, 2020 Craniosynostosis 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SNRI only 1.56 [0.64;3.83] -/-   0/- - -
ref
S11696
R43034		 Bérard b - SNRI=Venlafaxine (Controls unexposed, sick), 2017 Craniosynostosis 1st trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes Monotherapy: SNRI only Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 1.41 [0.57;3.52] -/738   -/14,847 - 738
ref
Total 2 studies 1.48 [0.78;2.81] 0 738
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson - SNRI, 2020Anderson - SNRI, 2020 1.56[0.64; 3.83]--51%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Bérard b - SNRI=Venlafaxine (Controls unexposed, sick), 2017Bérard b - SNRI=Venlafaxine, 2017 1 1.41[0.57; 3.52]-73849%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.48[0.78; 2.81]-7380.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.41[0.57; 3.50]-738 -NABérard b - SNRI=Venlafaxine (Controls unexposed, sick), 2017 1 case control studiescase control studies 1.56[0.64; 3.82]-- -NAAnderson - SNRI, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.56[0.64; 3.82]-- -NAAnderson - SNRI, 2020 1 unexposed, sickunexposed, sick 1.41[0.57; 3.50]-738 -NABérard b - SNRI=Venlafaxine (Controls unexposed, sick), 2017 1 Tags Adjustment   - Yes  - Yes 1.48[0.78; 2.81]-7380%NAAnderson - SNRI, 2020 Bérard b - SNRI=Venlafaxine (Controls unexposed, sick), 2017 2 Monotherapy   - SNRI only  - SNRI only 1.48[0.78; 2.81]-7380%NAAnderson - SNRI, 2020 Bérard b - SNRI=Venlafaxine (Controls unexposed, sick), 2017 2 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 1.41[0.57; 3.50]-738 -NABérard b - SNRI=Venlafaxine (Controls unexposed, sick), 2017 1 All studiesAll studies 1.48[0.78; 2.81]-7380%NAAnderson - SNRI, 2020 Bérard b - SNRI=Venlafaxine (Controls unexposed, sick), 2017 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.56[0.64; 3.82]-- -NAAnderson - SNRI, 2020 1 unexposed, sick controlsunexposed, sick controls 1.41[0.57; 3.50]-738 -NABérard b - SNRI=Venlafaxine (Controls unexposed, sick), 2017 10.510.01.0