Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) - Medication and Pregnancy KB

Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) updated on 07-01-2025

Jaundice / Icterus

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S13145 R50178	Marks - Duloxetine (Controls exposed to Bupropion), 2021	Jaundice	during pregnancy (anytime or not specified)	retrospective cohort	exposed to other treatment, sick	Adjustment: No Monotherapy: SNRI only	0.97 [0.57;1.66] ^C	21/139 63/406	84	139		ref
S11693 R43006	Reis - SNRI (Controls exposed to TCA), 2010	Jaundice	2nd and/or 3rd trimester	population based cohort retrospective	exposed to other treatment, sick excluded	Adjustment: No Monotherapy: SNRI only	1.18 [0.76;1.85] ^C excluded (control group)	37/538 46/784	83	538		ref
S11694 R43018	Reis - SNRI (Controls unexposed, NOS), 2010	Jaundice	2nd and/or 3rd trimester	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: SNRI only	1.46 [1.04;2.05]	37/538 52,004/1,062,190	52,041	538		ref
					Total	2 studies	1.26 [0.85;1.85]		52,125	677
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls exposed to Bupropion; 2: Controls unexposed, NOS;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 11693