| id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S18317 R77153 |
Chan (Controls unexposed, sick), 2024 | Ventral septal defect (VSD) | 1st trimester | retrospective cohort (claims database) | unexposed, sick | Adjustment: Yes Monotherapy: SNRI only Unexposed sick: old history of illness/treatment (> 12 months before pregnancy) or not specified | 2.01 [0.27;15.00] | 1/66 32/4,413 | 33 | 66 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S18315 R77129 |
Chan - SNRI (Controls exposed to TCA), 2024 | Ventral septal defect (VSD) | 1st trimester | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: No Monotherapy: SNRI only |
1.40 [0.14;13.64] C excluded (control group) |
1/77 3/322 | 4 | 77 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S18316 R77141 |
Chan - SNRI (Controls unexposed, general pop), 2024 | Ventral septal defect (VSD) | 1st trimester | retrospective cohort (claims database) | unexposed (general population or NOS) excluded | Adjustment: Yes Monotherapy: SNRI only |
0.84 [0.04;15.88] excluded (control group) |
1/77 2,586/462,377 | 2,587 | 77 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S11771 R43260 |
Anderson - SNRI, 2020 | Ventricular septal defect (VSD) – perimembranous type | 1st trimester | case control | unexposed (general population or NOS) | Adjustment: Yes Monotherapy: SNRI only | 2.06 [0.89;4.78] | -/- 0/- | - | - |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S11718 R43074 |
Huybrechts - SNRI (Controls unexposed, NOS), 2014 | Ventricular Septal Defect | 1st trimester | cohort | unexposed (general population or NOS) excluded | Adjustment: No Monotherapy: no or not specified |
1.56 [1.14;2.14] excluded (control group) |
39/6,904 3,212/885,115 | 3,251 | 6,904 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S11719 R43078 |
Huybrechts - SNRI (Controls unexposed, sick), 2014 | Ventricular Septal Defect | 1st trimester | cohort | unexposed, sick | Adjustment: Yes Monotherapy: no or not specified Unexposed sick: old history of illness/treatment (> 12 months before pregnancy) or not specified | 1.18 [0.80;1.73] | 34/5,993 751/180,564 | 785 | 5,993 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Total | 3 studies | 1.32 [0.93;1.86] | 818 | 6,059 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1: Controls unexposed, sick; 2: Controls unexposed, sick;
Funnel plot not drawn. Less than 3 points.
Asymetry test p-value = NaN (by Egger's regression)
not enought points
Funnel plot not drawn. Less than 3 points.
excluded 11718, 18315, 18316