Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) updated on 07-01-2025

Cleft lip with or without cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18325
R77199		 Laspro - Venlafaxine, 2024 Any cleft lip (ICD 10 codes Q36 or Q37) during pregnancy (anytime or not specified) excluded nested case control unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.58 [1.24;2.02]
excluded (exposition period) 		65/-   6,174/- 6,239 -
ref
S11771
R43268		 Anderson - SNRI, 2020 Cleft lip w/without cleft palate 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: SNRI only 1.97 [1.01;3.87] -/-   0/- - -
ref
Total 1 studies 1.97 [1.01;3.86] 0 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson - SNRI, 2020Anderson - SNRI, 2020 1.97[1.01; 3.87]--0%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.97[1.01; 3.86]-- -NAAnderson - SNRI, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.97[1.01; 3.86]-- -NAAnderson - SNRI, 2020 1 Tags Adjustment   - Yes  - Yes 1.97[1.01; 3.86]-- -NAAnderson - SNRI, 2020 1 Monotherapy   - SNRI only  - SNRI only 1.97[1.01; 3.86]-- -NAAnderson - SNRI, 2020 1 All studiesAll studies 1.97[1.01; 3.86]-- -NAAnderson - SNRI, 2020 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.97[1.01; 3.86]-- -NAAnderson - SNRI, 2020 10.510.01.0