| id | Study | Lib. in paper | Exposition period | Study type |
Control type |
Tags | OR 95%CI | x1/n1 x0/n0 | no cases | no exposed | ROB | Ref. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S18440 R78228 |
Lee (Controls exposed to TCAs), 2025 | Postpartum haemorrhage | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | exposed to other treatment, sick excluded | Adjustment: No Monotherapy: SNRI only |
1.86 [0.69;5.04] C excluded (control group) |
5/71 24/613 | 29 | 71 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S18441 R78249 |
Lee (Controls unexposed, general pop), 2025 | Postpartum haemorrhage | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes Monotherapy: SNRI only | 1.40 [0.56;3.49] | 5/71 19,755/463,440 | 19,760 | 71 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S18335 R77359 |
Jackson - SNRI, 2024 | Post-partum hemorrhage (ICD-10 diagnosis code for PPH and a procedure code for blood transfusion) | during pregnancy (anytime or not specified) | retrospective cohort (claims database) | unexposed, disease free | Adjustment: Yes Monotherapy: SNRI only | 2.14 [0.89;4.34] | 7/145 3,124/106,961 | 3,131 | 145 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S11745 R43128 |
Huybrechts - Duloxetine (Controls unexposed, NOS), 2020 | Postpartum hemorrhage (ICD-9 diagnostic codes 666.xx) | late pregnancy | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes Monotherapy: no or not specified | 1.53 [1.08;2.18] | 34/955 95,988/4,128,460 | 96,022 | 955 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S11741 R43097 |
Hanley - SNRI, 2016 | Postpartum hemorrhage | late pregnancy | retrospective cohort (claims database) | unexposed (general population or NOS) | Adjustment: Yes Monotherapy: SNRI only | 1.64 [1.38;1.96] | 154/1,390 21,745/310,813 | 21,899 | 1,390 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| S11738 R43094 |
Palmsten b - SNRI, 2013 | Postpartum hemorrhage (ICD-9 code for 666.x) | late pregnancy | retrospective cohort (claims database) | unexposed, sick | Adjustment: Yes Monotherapy: SNRI only Unexposed sick: old history of illness/treatment (> 12 months before pregnancy) or not specified | 1.90 [1.37;2.63] | 35/702 1,896/69,044 | 1,931 | 702 |
|
ref | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Total | 5 studies | 1.67 [1.46;1.92] | 142,743 | 3,263 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1: Controls unexposed, general pop; 2: Controls unexposed, NOS;
Asymetry test p-value = 0.7483 (by Egger's regression)
slope=0.4869 (0.0921); intercept=0.2062 (0.5863); t=0.3517; p=0.7483
excluded 18440