Serotonin and Noradrenaline Reuptake Inhibitors (SNRI) updated on 07-01-2025

Neuro-developmental disorders (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18333
R77344		 Suarez - SNRI (Controls unexposed, discontinuers), 2022 Any Specific Neurodevelopmental Disorder (ASD, ADHD, language disorder, learning disorders, intellectual disability, Developmental Coordination Disorder) 2nd and/or 3rd trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes Monotherapy: no or not specified Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 1.03 [0.86;1.22] 658/8,540   354/4,899 1,012 8,540
ref
S18334
R77355		 Suarez - SNRI (Controls unexposed, general pop), 2022 Any Specific Neurodevelopmental Disorder (ASD, ADHD, language disorder, learning disorders, intellectual disability, Developmental Coordination Disorder) 2nd and/or 3rd trimester retrospective cohort (claims database) unexposed (general population or NOS) excluded Adjustment: Yes Monotherapy: no or not specified 1.18 [1.08;1.28]
excluded (control group) 		666/8,659   131,743/2,910,114 132,409 8,659
ref
Total 1 studies 1.03 [0.86;1.23] 1,012 8,540
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Suarez - SNRI (Controls unexposed, discontinuers), 2022Suarez - SNRI, 2022 1 1.03[0.86; 1.22]1,0128,5400%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, discontinuers;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.03[0.86; 1.23]1,0128,540 -NASuarez - SNRI (Controls unexposed, discontinuers), 2022 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.03[0.86; 1.23]1,0128,540 -NASuarez - SNRI (Controls unexposed, discontinuers), 2022 1 Tags Adjustment   - Yes  - Yes 1.03[0.86; 1.23]1,0128,540 -NASuarez - SNRI (Controls unexposed, discontinuers), 2022 1 Monotherapy   - no or not specified  - no or not specified 1.03[0.86; 1.23]1,0128,540 -NASuarez - SNRI (Controls unexposed, discontinuers), 2022 1 Unexposed sick   - recent illness/treatment (during o ...  - recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 1.03[0.86; 1.23]1,0128,540 -NASuarez - SNRI (Controls unexposed, discontinuers), 2022 1 All studiesAll studies 1.03[0.86; 1.23]1,0128,540 -NASuarez - SNRI (Controls unexposed, discontinuers), 2022 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18334

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.18[1.08; 1.28]132,4098,659 -NASuarez - SNRI (Controls unexposed, general pop), 2022 1 unexposed, sick controlsunexposed, sick controls 1.03[0.86; 1.23]1,0128,540 -NASuarez - SNRI (Controls unexposed, discontinuers), 2022 10.510.01.0