Bupropion (All indications except smoking cessation) updated on 07-01-2025

Nervous system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12933
R49088		 Cole, 2007 Central nervous system malformations 1st trimester retrospective cohort (claims database) exposed to other treatment, sick Adjustment: No Indications Bupropion: Any or not mentioned Monotherapy: no or not specified 0.23 [0.01;3.98] C 0/1,213   8/4,743 8 1,213
ref
Total 1 studies 0.23 [0.01;3.98] 8 1,213
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cole, 2007Cole, 2007 0.23[0.01; 3.98]81,2130%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.23[0.01; 3.98]81,213 -NACole, 2007 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.23[0.01; 3.98]81,213 -NACole, 2007 1 Tags Adjustment   - No  - No 0.23[0.01; 3.98]81,213 -NACole, 2007 1 Indications Bupropion   - Any or not mentioned  - Any or not mentioned 0.23[0.01; 3.98]81,213 -NACole, 2007 1 Monotherapy   - no or not specified  - no or not specified 0.23[0.01; 3.98]81,213 -NACole, 2007 1 All studiesAll studies 0.23[0.01; 3.98]81,213 -NACole, 2007 10.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.23[0.01; 3.98]81,213 -NACole, 2007 10.510.01.0