Bupropion (All indications except smoking cessation) - Medication and Pregnancy KB

Bupropion (All indications except smoking cessation) updated on 07-01-2025

Severe cognitive developmental delay (Mental retardation) (3-6 years old)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S18331 R77320	Suarez (Controls unexposed, discontinuers), 2022	Intellectual disability - ≥ 2 dates with ICD-9 Dx 317, 318.x, 319 - At ≥ 2 years of age	2nd and/or 3rd trimester	retrospective cohort (claims database)	unexposed, sick	Adjustment: Yes Monotherapy: no or not specified Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy)	1.99 [0.90;4.37]	30/12,756 -/4,360	-	12,756		ref
S18332 R77331	Suarez (Controls unexposed, general pop), 2022	Intellectual disability - ≥ 2 dates with ICD-9 Dx 317, 318.x, 319 - At ≥ 2 years of age	2nd and/or 3rd trimester	retrospective cohort (claims database)	unexposed (general population or NOS) excluded	Adjustment: Yes Monotherapy: no or not specified	1.06 [0.71;1.56] excluded (control group)	30/12,794 2,875/1,785,311	2,905	12,794		ref
					Total	1 studies	1.99 [0.90;4.39]		0	12,756
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, discontinuers;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18332