Bupropion (All indications except smoking cessation) updated on 07-01-2025

Ear malformations

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12933
R49089
Cole, 2007 Ear malformations 1st trimester retrospective cohort (claims database) exposed to other treatment, sick Adjustment: No Indications Bupropion: Any or not mentioned Monotherapy: no or not specified 3.91 [0.08;197.23] C 0/1,213   0/4,743 0 1,213
ref
Total 1 studies 3.91 [0.08;197.23] 0 1,213
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Cole, 2007Cole, 2007 3.91[0.08; 197.23]01,2130%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.91[0.08; 197.23]-1,213 -NACole, 2007 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 3.91[0.08; 197.23]-1,213 -NACole, 2007 1 Tags Adjustment   - No  - No 3.91[0.08; 197.23]-1,213 -NACole, 2007 1 Indications Bupropion   - Any or not mentioned  - Any or not mentioned 3.91[0.08; 197.23]-1,213 -NACole, 2007 1 Monotherapy   - no or not specified  - no or not specified 3.91[0.08; 197.23]-1,213 -NACole, 2007 1 All studiesAll studies 3.91[0.08; 197.23]-1,213 -NACole, 2007 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 3.91[0.08; 197.23]-1,213 -NACole, 2007 10.510.01.0