Bupropion (All indications except smoking cessation) updated on 07-01-2025

Neonatal medical care

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13149
R50197		 Marks (Controls exposed to Sertraline), 2021 Neonatal intensive care unit admission during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick Adjustment: Yes Indications Bupropion: Any or not mentioned Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.87 [0.71;1.06] 91/406   384/1,653 475 406
ref
Total 1 studies 0.87 [0.71;1.06] 475 406
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Marks (Controls exposed to Sertraline), 2021Marks, 2021 1 0.87[0.71; 1.06]4754060%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls exposed to Sertraline;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.87[0.71; 1.06]475406 -NAMarks (Controls exposed to Sertraline), 2021 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.87[0.71; 1.06]475406 -NAMarks (Controls exposed to Sertraline), 2021 1 Tags Adjustment   - Yes  - Yes 0.87[0.71; 1.06]475406 -NAMarks (Controls exposed to Sertraline), 2021 1 Indications Bupropion   - Any or not mentioned  - Any or not mentioned 0.87[0.71; 1.06]475406 -NAMarks (Controls exposed to Sertraline), 2021 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 0.87[0.71; 1.06]475406 -NAMarks (Controls exposed to Sertraline), 2021 1 All studiesAll studies 0.87[0.71; 1.06]475406 -NAMarks (Controls exposed to Sertraline), 2021 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.87[0.71; 1.06]475406 -NAMarks (Controls exposed to Sertraline), 2021 10.510.01.0