Citalopram updated on 07-01-2025

Neonatal disorders (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18431
R78042		 Lee (Controls exposed to TCAs), 2025 Any neonatal outcomes (preterm, low birth weight, small for gestational age, large for gestational age, low Apgar score, during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.56 [0.96;2.52] C
excluded (control group) 		52/81   328/613 380 81
ref
S18412
R77779		 Lee (Controls unexposed, general pop), 2025 Any neonatal outcomes (preterm, low birth weight, small for gestational age, large for gestational age, low Apgar score, during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 2.56 [1.62;4.04] 52/81   161,405/463,440 161,457 81
ref
S6414
R17601		 Sivojelezova (Control unexposed, NOS), 2005 Neonatal complications in general 3rd trimester prospective cohort unexposed (general population or NOS) Adjustment: No Matched Monotherapy: no or not specified 1.50 [1.00;2.40] 20/63   33/158 53 63
ref
Total 2 studies 1.95 [1.16;3.29] 161,510 144
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lee (Controls unexposed, general pop), 2025Lee, 2025 1 2.56[1.62; 4.04]161,4578149%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Sivojelezova (Control unexposed, NOS), 2005Sivojelezova, 2005 2 1.50[1.00; 2.40]536351%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 64% 1.95[1.16; 3.29]161,5101440.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, general pop; 2: Control unexposed, NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.95[1.16; 3.29]161,51014464%NALee (Controls unexposed, general pop), 2025 Sivojelezova (Control unexposed, NOS), 2005 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.95[1.16; 3.29]161,51014464%NALee (Controls unexposed, general pop), 2025 Sivojelezova (Control unexposed, NOS), 2005 2 Tags Adjustment   - No  - No 1.50[0.97; 2.32]5363 -NASivojelezova (Control unexposed, NOS), 2005 1   - Yes  - Yes 2.56[1.62; 4.04]161,45781 -NALee (Controls unexposed, general pop), 2025 1 MatchedMatched 1.50[0.97; 2.32]5363 -NASivojelezova (Control unexposed, NOS), 2005 1 Monotherapy   - no or not specified  - no or not specified 1.50[0.97; 2.32]5363 -NASivojelezova (Control unexposed, NOS), 2005 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 2.56[1.62; 4.04]161,45781 -NALee (Controls unexposed, general pop), 2025 1 All studiesAll studies 1.95[1.16; 3.29]161,51014464%NALee (Controls unexposed, general pop), 2025 Sivojelezova (Control unexposed, NOS), 2005 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18431

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.95[1.16; 3.29]161,51014464%NALee (Controls unexposed, general pop), 2025 Sivojelezova (Control unexposed, NOS), 2005 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.56[0.96; 2.52]38081 -NALee (Controls exposed to TCAs), 2025 10.510.01.0