Citalopram updated on 07-01-2025

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18431
R78044		 Lee (Controls exposed to TCAs), 2025 Low birth weight (birth weight <2500 g) during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.67 [0.89;3.14] C
excluded (control group) 		14/81   68/613 82 81
ref
S18412
R77781		 Lee (Controls unexposed, general pop), 2025 Low birth weight (birth weight <2500 g) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.83 [1.03;3.27] 14/81   31,347/463,440 31,361 81
ref
S7696
R22825		 Kivistö, 2016 Low birth weight (<2500 g) during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.42 [0.86;2.32] -/215   1,573/24,402 - 215
ref
S7179
R20202		 Colvin, 2011 Birth weight <2500 g during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.58 [1.31;1.91] 125/1,157   6,744/94,561 6,869 1,157
ref
Total 3 studies 1.58 [1.34;1.87] 38,230 1,453
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lee (Controls unexposed, general pop), 2025Lee, 2025 1 1.83[1.03; 3.27]31,361819%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Kivistö, 2016Kivistö, 2016 1.42[0.86; 2.32]-21512%ROB confusion: seriousROB selection: criticalROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate Colvin, 2011Colvin, 2011 1.58[1.31; 1.91]6,8691,15780%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 1.58[1.34; 1.87]38,2301,4530.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, general pop;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.58[1.34; 1.87]38,2301,4530%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 Colvin, 2011 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.58[1.34; 1.87]38,2301,4530%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 Colvin, 2011 3 Tags Adjustment   - No  - No 1.58[1.31; 1.91]6,8691,157 -NAColvin, 2011 1   - Yes  - Yes 1.58[1.09; 2.30]31,3612960%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 2 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.58[1.09; 2.30]31,3612960%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 2   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.58[1.31; 1.91]6,8691,157 -NAColvin, 2011 1 All studiesAll studies 1.58[1.34; 1.87]38,2301,4530%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 Colvin, 2011 30.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18431

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.58[1.34; 1.87]39,7941,4530%NALee (Controls unexposed, general pop), 2025 Kivistö, 2016 Colvin, 2011 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.67[0.89; 3.14]8281 -NALee (Controls exposed to TCAs), 2025 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Vlenterie (Low birth weigh (< 2500 grams))Vlenterie (Low birth weigh (< 2500 grams)) 1.10[0.40; 2.90]-U,GPunexposed (general population or NOS)Anyduring pregnancy (anytime or not specified)studies TTT8 Vlenterie (Low birth weigh (< 2500 grams))Vlenterie (Low birth weigh (< 2500 grams)) 1.00[0.40; 2.50]-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT8 Xing (Low birth weight)Xing (Low birth weight) 1.56[1.31; 1.86]0%-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT2 metaPregmetaPreg 1.58[1.34; 1.87]0%1,453----Lee (Controls unexposed, general pop), 2025 Kivistö, 2016 Colvin, 2011 30.510.01.0