Citalopram updated on 07-01-2025

Late intrauterine deaths (> 22 weeks) / Stillbirths

id	Study   Auto Stephansson, 2013Colvin, 2011Sivojelezova (Control exposed to other SSRI), 2005Sivojelezova (Control unexposed, NOS), 2005	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimesterPaternal exp. genotoxic window only (0–3 months preconception)Paternal exposure: epigenetic window only (3–xxx months preconception)Paternal exposure: genotoxic/epigenetic window (0–xxx months preconception)Paternal exposure: other window	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S7925 R23987	Stephansson, 2013	Stillbirth (after 22 weeks of gestation)	3 months (or more) before pregnancy or during pregnancy excluded	population based cohort retrospective	unexposed (general population or NOS)	Adjustment: No Monotherapy: no or not specified	0.99 [0.71;1.39] C excluded (exposition period)	34/9,278   5,919/1,604,649	5,953	9,278		ref
S7179 R20204	Colvin, 2011	Stillbirths	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...)	0.93 [0.44;1.97]	7/1,157   612/94,561	619	1,157		ref
S6415 R17605	Sivojelezova (Control exposed to other SSRI), 2005	Stillbirth	during pregnancy (anytime or not specified)	prospective cohort	exposed to other treatment, sick excluded	Adjustment: No Matched Monotherapy: no or not specified	5.08 [0.24;106.79] C excluded (control group)	2/132   0/132	2	132		ref
S6414 R17597	Sivojelezova (Control unexposed, NOS), 2005	Stillbirth	during pregnancy (anytime or not specified)	prospective cohort	unexposed (general population or NOS)	Adjustment: No Matched Monotherapy: no or not specified	2.02 [0.18;22.50] C	2/132   1/132	3	132		ref
					Total	2 studies	1.00 [0.49;2.04]		622	1,289
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 6415

Umbrella review (other published meta-analyses)