Citalopram updated on 07-01-2025

Child/Infant death (> 28 days of life)

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18431
R78052
Lee (Controls exposed to TCAs), 2025 Infant death (29–365 days after birth) during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 7.61 [0.15;386.13] C
excluded (control group)
0/81   0/613 0 81
ref
S18412
R77789
Lee (Controls unexposed, general pop), 2025 Infant death (29–365 days after birth) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 22.05 [1.36;357.49] C 0/81   130/463,440 130 81
ref
S7925
R23989
Stephansson, 2013 Postneonatal death (death between 28-364 days among neonatal survivors) 3 months (or more) before pregnancy or during pregnancy excluded population based cohort retrospective unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.59 [0.94;2.68] C
excluded (exposition period)
14/9,217   1,538/1,604,649 1,552 9,217
ref
S7219
R20550
Colvin, 2012 Death before 1 year during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.08 [0.64;1.84] 14/-   1,058/94,561 1,072 -
ref
Total 2 studies 3.53 [0.20;63.43] 1,202 81
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lee (Controls unexposed, general pop), 2025Lee, 2025 1 22.05[1.36; 357.49]1308139%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Colvin, 2012Colvin, 2012 1.08[0.64; 1.84]1,072-61%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 77% 3.53[0.20; 63.43]1,202810.550.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, general pop;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.53[0.20; 63.43]1,2028177%NALee (Controls unexposed, general pop), 2025 Colvin, 2012 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.53[0.20; 63.43]1,2028177%NALee (Controls unexposed, general pop), 2025 Colvin, 2012 2 Tags Adjustment   - No  - No 3.53[0.20; 63.43]1,2028177%NALee (Controls unexposed, general pop), 2025 Colvin, 2012 2 Monotherapy   - no or not specified  - no or not specified 1.08[0.64; 1.83]1,072- -NAColvin, 2012 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 22.05[1.36; 357.49]13081 -NALee (Controls unexposed, general pop), 2025 1 All studiesAll studies 3.53[0.20; 63.43]1,2028177%NALee (Controls unexposed, general pop), 2025 Colvin, 2012 20.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18431

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.53[0.20; 63.43]1,2028177%NALee (Controls unexposed, general pop), 2025 Colvin, 2012 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 7.61[0.15; 386.13]-81 -NALee (Controls exposed to TCAs), 2025 10.510.01.0