Citalopram updated on 07-01-2025

Omphalocele

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8214
R25527
Jordan, 2016 Omphalocele 3 months or more before pregnancy or1st trimester excluded retrospective cohort (registry) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 0.68 [0.04;10.94] C
excluded (exposition period)
0/4,028   92/506,155 92 4,028
ref
S6161
R16188
Louik, 2007 Omphalocele 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.49 [0.09;25.05] C 0/15   127/5,972 127 15
ref
Total 1 studies 1.49 [0.09;25.05] 127 15
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Louik, 2007Louik, 2007 1.49[0.09; 25.05]127150%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.49[0.09; 25.05]12715 -NALouik, 2007 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.49[0.09; 25.05]12715 -NALouik, 2007 1 Tags Adjustment   - No  - No 1.49[0.09; 25.05]12715 -NALouik, 2007 1 Monotherapy   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.49[0.09; 25.05]12715 -NALouik, 2007 1 All studiesAll studies 1.49[0.09; 25.05]12715 -NALouik, 2007 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.49[0.09; 25.05]12715 -NALouik, 2007 10.510.01.0