Citalopram updated on 07-01-2025

Ectopic pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7179
R20218		 Colvin, 2011 Ectopic pregnancy 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.00 [0.56;1.77] 12/1,012   1,483/119,840 1,495 1,012
ref
S6415
R17606		 Sivojelezova (Control exposed to other SSRI), 2005 Ectopic pregnancy during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No Matched Monotherapy: no or not specified 0.14 [0.01;2.73] C
excluded (control group) 		0/132   3/132 3 132
ref
S6414
R17598		 Sivojelezova (Control unexposed, NOS), 2005 Ectopic pregnancy during pregnancy (anytime or not specified) excluded prospective cohort unexposed (general population or NOS) Adjustment: No Matched Monotherapy: no or not specified 1.00 [0.02;50.78] C
excluded (exposition period) 		0/132   0/132 0 132
ref
Total 1 studies 1.00 [0.56;1.78] 1,495 1,012
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Colvin, 2011Colvin, 2011 1.00[0.56; 1.77]1,4951,0120%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.52.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.00[0.56; 1.78]1,4951,012 -NAColvin, 2011 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.00[0.56; 1.78]1,4951,012 -NAColvin, 2011 1 Tags Adjustment   - No  - No 1.00[0.56; 1.78]1,4951,012 -NAColvin, 2011 1 Monotherapy   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.00[0.56; 1.78]1,4951,012 -NAColvin, 2011 1 All studiesAll studies 1.00[0.56; 1.78]1,4951,012 -NAColvin, 2011 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6415

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.00[0.56; 1.78]1,4951,012 -NAColvin, 2011 10.510.01.0