Citalopram updated on 07-01-2025

Club foot / Talipes equinovarus

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6005
R15390		 Furu, 2015 Clubfoot 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.56 [1.05;2.30] 27/11,193   3,174/2,266,875 3,201 11,193
ref
S7351
R21505		 Wemakor, 2015 Club foot 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.91 [0.71;5.11] 5/25   1,987/19,050 1,992 25
ref
S7907
R23944		 Yazdy, 2014 Club foot 1st trimester case control unexposed, disease free Adjustment: Yes Monotherapy: no or not specified 0.90 [0.20;3.40] 4/13   618/2,611 622 13
ref
S6161
R16198		 Louik, 2007 Clubfoot 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 2.70 [0.50;13.10] 2/17   411/6,256 413 17
ref
Total 4 studies 1.59 [1.12;2.24] 6,228 11,248
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Furu, 2015Furu, 2015 1.56[1.05; 2.30]3,20111,19377%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Wemakor, 2015Wemakor, 2015 1.91[0.71; 5.11]1,9922512%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Yazdy, 2014Yazdy, 2014 0.90[0.20; 3.40]622136%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Louik, 2007Louik, 2007 2.70[0.50; 13.10]413174%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (4 studies) I2 = 0% 1.59[1.12; 2.24]6,22811,2480.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.56[1.05; 2.31]3,20111,193 -NAFuru, 2015 1 case control studiescase control studies 1.68[0.81; 3.47]3,027550%NAWemakor, 2015 Yazdy, 2014 Louik, 2007 3 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.59[1.12; 2.24]6,22811,2480%NAFuru, 2015 Wemakor, 2015 Yazdy, 2014 Louik, 2007 4 Tags Adjustment   - Yes  - Yes 1.59[1.12; 2.24]6,22811,2480%NAFuru, 2015 Wemakor, 2015 Yazdy, 2014 Louik, 2007 4 Monotherapy   - no or not specified  - no or not specified 0.90[0.22; 3.71]62213 -NAYazdy, 2014 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.60[1.11; 2.31]5,19311,2180%NAFuru, 2015 Wemakor, 2015 2   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 2.70[0.53; 13.82]41317 -NALouik, 2007 1 All studiesAll studies 1.59[1.12; 2.24]6,22811,2480%NAFuru, 2015 Wemakor, 2015 Yazdy, 2014 Louik, 2007 40.210.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-2.02.41.0000.000Furu, 2015Wemakor, 2015Yazdy, 2014Louik, 2007

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.59[1.12; 2.24]6,22811,2480%NAFuru, 2015 Wemakor, 2015 Yazdy, 2014 Louik, 2007 40.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Chen (Clubfoot)Chen (Clubfoot) 1.64[1.16; 2.30]0 %-Wwhatever (meta-analysis)T11st trimesterstudies TTT4 metaPregmetaPreg 1.59[1.12; 2.24]0%11,248----Furu, 2015 Wemakor, 2015 Yazdy, 2014 Louik, 2007 40.510.01.0