Citalopram updated on 07-01-2025

Cleft lip with or without cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18238
R76506		 Laspro, 2024 Any cleft lip (ICD 10 codes Q36 or Q37) during pregnancy (anytime or not specified) excluded nested case control unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.27 [1.04;1.54]
excluded (exposition period) 		102/-   6,137/- 6,239 -
ref
S7471
R22310		 Anderson, 2020 Cleft lip w/without cleft palate 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.11 [0.57;2.19] -/-   0/- - -
ref
S8214
R25522		 Jordan, 2016 Cleft lip with or without palate 3 months or more before pregnancy or1st trimester excluded retrospective cohort (registry) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 0.67 [0.22;2.08] C
excluded (exposition period) 		3/4,028   563/506,155 566 4,028
ref
S6241
R16483		 Malm, 2011 Cleft lip with or without cleft palate 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 0.62 [0.15;2.52] -/2,799   -/628,607 - 2,799
ref
S6161
R16194		 Louik, 2007 Cleft lip with or without cleft palate 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 3.20 [0.90;11.90] 4/19   700/6,545 704 19
ref
Total 3 studies 1.27 [0.59;2.75] 704 2,818
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.11[0.57; 2.19]--53%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Malm, 2011Malm, 2011 0.62[0.15; 2.52]-2,79922%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Louik, 2007Louik, 2007 3.20[0.90; 11.90]7041925%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (3 studies) I2 = 36% 1.27[0.59; 2.75]7042,8180.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.62[0.15; 2.54]-2,799 -NAMalm, 2011 1 case control studiescase control studies 1.62[0.60; 4.39]7041951%NAAnderson, 2020 Louik, 2007 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.27[0.59; 2.75]7042,81836%NAAnderson, 2020 Malm, 2011 Louik, 2007 3 Tags Adjustment   - Yes  - Yes 1.27[0.59; 2.75]7042,81836%NAAnderson, 2020 Malm, 2011 Louik, 2007 3 Monotherapy   - no or not specified  - no or not specified 0.62[0.15; 2.54]-2,799 -NAMalm, 2011 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.11[0.57; 2.18]-- -NAAnderson, 2020 1   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 3.20[0.88; 11.64]70419 -NALouik, 2007 1 All studiesAll studies 1.27[0.59; 2.75]7042,81836%NAAnderson, 2020 Malm, 2011 Louik, 2007 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.27[0.59; 2.75]7042,81836%NAAnderson, 2020 Malm, 2011 Louik, 2007 30.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Reefhuis (Cleft lip with or without cleft palate)Reefhuis (Cleft lip with or without cleft palate) 1.40[0.70; 2.70]NA-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT2 metaPregmetaPreg 1.27[0.59; 2.75]36%2,818----Anderson, 2020 Malm, 2011 Louik, 2007 30.510.01.0