Citalopram updated on 07-01-2025

Preeclampsia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6948
R19618		 Palmsten (Controls exposed to TCA), 2013 Preeclampsia and/or eclampsia (ICD-9 codes 642.4x–642.7x, after 140 gestational days and within 30 days after the delivery) 2nd and/or 3rd trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.48 [0.33;0.69] C
excluded (control group) 		91/1,680   47/441 138 1,680
ref
S6214
R16391		 Palmsten (Controls unexposed, sick), 2013 Preeclampsia and/or eclampsia (ICD-9 codes 642.4x–642.7x, after 140 gestational days and within 30 days after the delivery) 2nd and/or 3rd trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 1.01 [0.82;1.23] 91/1,680   3,215/59,219 3,306 1,680
ref
S5951
R15266		 De Vera, 2012 Pregnancy-induced hypertension (gestational hypertension, pre-eclampsia, or eclampsia after the 20th week of gestation) during pregnancy (anytime or not specified) nested case control unexposed (general population or NOS) Adjustment: Yes Matched Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.94 [0.21;4.10] 2/-   1,214/- 1,216 -
ref
Total 2 studies 1.01 [0.83;1.23] 4,522 1,680
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Palmsten (Controls unexposed, sick), 2013Palmsten, 2013 1 1.01[0.82; 1.23]3,3061,68098%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA De Vera, 2012De Vera, 2012 0.94[0.21; 4.10]1,216-2%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.01[0.83; 1.23]4,5221,6800.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.01[0.82; 1.24]3,3061,680 -NAPalmsten (Controls unexposed, sick), 2013 1 case control studiescase control studies 0.94[0.21; 4.15]1,216- -NADe Vera, 2012 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.94[0.21; 4.15]1,216- -NADe Vera, 2012 1 unexposed, sickunexposed, sick 1.01[0.82; 1.24]3,3061,680 -NAPalmsten (Controls unexposed, sick), 2013 1 Tags Adjustment   - Yes  - Yes 1.01[0.83; 1.23]4,5221,6800%NAPalmsten (Controls unexposed, sick), 2013 De Vera, 2012 2 MatchedMatched 0.94[0.21; 4.15]1,216- -NADe Vera, 2012 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.01[0.83; 1.23]4,5221,6800%NAPalmsten (Controls unexposed, sick), 2013 De Vera, 2012 2 Unexposed sick   - recent illness/treatment (during o ...  - recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 1.01[0.82; 1.24]3,3061,680 -NAPalmsten (Controls unexposed, sick), 2013 1 All studiesAll studies 1.01[0.83; 1.23]4,5221,6800%NAPalmsten (Controls unexposed, sick), 2013 De Vera, 2012 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 6948

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.94[0.21; 4.15]1,216- -NADe Vera, 2012 1 unexposed, sick controlsunexposed, sick controls 1.01[0.82; 1.24]3,3061,680 -NAPalmsten (Controls unexposed, sick), 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.48[0.33; 0.69]1381,680 -NAPalmsten (Controls exposed to TCA), 2013 10.510.01.0