Citalopram updated on 07-01-2025

Neonatal medical care

id	Study   Auto Lee (Controls exposed to TCAs), 2025Lee (Controls unexposed, general pop), 2025Cornet, 2024Marks (Controls exposed to Bupropion), 2021Kivistö, 2016Sivojelezova (Control unexposed, NOS), 2005	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimesterPaternal exp. genotoxic window only (0–3 months preconception)Paternal exposure: epigenetic window only (3–xxx months preconception)Paternal exposure: genotoxic/epigenetic window (0–xxx months preconception)Paternal exposure: other window	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedsiblingwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S18431 R78050	Lee (Controls exposed to TCAs), 2025	Admission to neonatal intensive care unit (NICU)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	1.46 [0.49;4.38] C excluded (control group)	4/81   21/613	25	81		ref
S18412 R77787	Lee (Controls unexposed, general pop), 2025	Admission to neonatal intensive care unit (NICU)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	1.34 [0.49;3.68]	4/81   8,566/463,440	8,570	81		ref
S18260 R76711	Cornet, 2024	Delayed neonatal adaptation (presence of at least one of the following: 5min Apgar score ≤5; positive pressure ventilation or intubation during delivery room resuscitation; or admission to the NICU with respiratory distress requiring invasive or non-invasive ventilation)	late pregnancy	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...)	2.29 [1.91;2.76]	-/825   12,078/272,517	-	825		ref
S13120 R50008	Marks (Controls exposed to Bupropion), 2021	Neonatal intensive care unit admission	during pregnancy (anytime or not specified)	retrospective cohort	exposed to other treatment, sick	Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	1.41 [0.98;2.03]	105/385   91/406	196	385		ref
S7696 R22822	Kivistö, 2016	Neonatal intensive care	during pregnancy (anytime or not specified)	retrospective cohort	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	2.12 [1.48;3.03]	-/215   2,431/24,402	-	215		ref
S6414 R17602	Sivojelezova (Control unexposed, NOS), 2005	Neonatal intensive care unit admission	3rd trimester	prospective cohort	unexposed (general population or NOS)	Adjustment: No Matched Monotherapy: no or not specified	4.20 [1.70;10.30]	10/63   6/158	16	63		ref
					Total	5 studies	2.02 [1.53;2.66]		8,782	1,569
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 18431