Amitriptyline - Medication and Pregnancy KB

Amitriptyline updated on 07-01-2025

Neonatal disorders (as a whole)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S18423 R77973	Lee (Controls exposed to SSRI), 2025	Any neonatal outcomes (preterm, low birth weight, small for gestational age, large for gestational age, low Apgar score,	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	0.90 [0.70;1.16] ^C excluded (control group)	149/301 763/1,465	912	301		ref
S18411 R77758	Lee (Controls unexposed, general pop), 2025	Any neonatal outcomes (preterm, low birth weight, small for gestational age, large for gestational age, low Apgar score,	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	1.36 [1.08;1.71]	149/301 161,405/463,440	161,554	301		ref
					Total	1 studies	1.36 [1.08;1.71]		161,554	301
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, general pop;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18423