Amitriptyline updated on 07-01-2025

Large for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18423
R77977		 Lee (Controls exposed to SSRI), 2025 Large for gestational age (birth weight >2 standard deviations above the mean for gestational age) during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.18 [0.02;1.36] C
excluded (control group) 		1/301   26/1,465 27 301
ref
S18411
R77762		 Lee (Controls unexposed, general pop), 2025 Large for gestational age (birth weight >2 standard deviations above the mean for gestational age) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.13 [0.02;0.89] 1/301   9,744/463,440 9,745 301
ref
Total 1 studies 0.13 [0.02;0.87] 9,745 301
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lee (Controls unexposed, general pop), 2025Lee, 2025 1 0.13[0.02; 0.89]9,7453010%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.02.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, general pop;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.13[0.02; 0.87]9,745301 -NALee (Controls unexposed, general pop), 2025 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.13[0.02; 0.87]9,745301 -NALee (Controls unexposed, general pop), 2025 1 Tags Adjustment   - Yes  - Yes 0.13[0.02; 0.87]9,745301 -NALee (Controls unexposed, general pop), 2025 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 0.13[0.02; 0.87]9,745301 -NALee (Controls unexposed, general pop), 2025 1 All studiesAll studies 0.13[0.02; 0.87]9,745301 -NALee (Controls unexposed, general pop), 2025 10.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18423

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale0.13[0.02; 0.87]9,745301 -NALee (Controls unexposed, general pop), 2025 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.18[0.02; 1.36]27301 -NALee (Controls exposed to SSRI), 2025 10.510.01.0