Amitriptyline updated on 07-01-2025

Small for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18423
R77976		 Lee (Controls exposed to SSRI), 2025 Small for gestational age (birth weight <2 standard deviations below the mean for gestational age) during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.14 [0.50;2.62] C
excluded (control group) 		7/301   30/1,465 37 301
ref
S18411
R77761		 Lee (Controls unexposed, general pop), 2025 Small for gestational age (birth weight <2 standard deviations below the mean for gestational age) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.20 [0.56;2.54] 7/301   6,986/463,440 6,993 301
ref
S18306
R77094		 Martin, 2024 Small for gestational age (SGA, defined as those with a birth weight in the lowest 10 percentiles for gestational age (<10th percentile) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.00 [0.90;1.11] 433/3,859   229,066/2,408,707 229,499 3,859
ref
Total 2 studies 1.00 [0.90;1.11] 236,492 4,160
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lee (Controls unexposed, general pop), 2025Lee, 2025 1 1.20[0.56; 2.54]6,9933012%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Martin, 2024Martin, 2024 1.00[0.90; 1.11]229,4993,85998%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.00[0.90; 1.11]236,4924,1600.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, general pop;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.00[0.90; 1.11]236,4924,1600%NALee (Controls unexposed, general pop), 2025 Martin, 2024 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.00[0.90; 1.11]236,4924,1600%NALee (Controls unexposed, general pop), 2025 Martin, 2024 2 Tags Adjustment   - Yes  - Yes 1.00[0.90; 1.11]236,4924,1600%NALee (Controls unexposed, general pop), 2025 Martin, 2024 2 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.00[0.90; 1.11]236,4924,1600%NALee (Controls unexposed, general pop), 2025 Martin, 2024 2 All studiesAll studies 1.00[0.90; 1.11]236,4924,1600%NALee (Controls unexposed, general pop), 2025 Martin, 2024 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18423

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.00[0.90; 1.11]236,4924,1600%NALee (Controls unexposed, general pop), 2025 Martin, 2024 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.14[0.50; 2.62]37301 -NALee (Controls exposed to SSRI), 2025 10.510.01.0