Amitriptyline updated on 07-01-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11597
R42497		 Ozturk, 2016 Miscarriages at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 2.26 [0.11;45.78] C 0/4   15/261 15 4
ref
S11208
R41261		 Kjaersgaard, 2013 Spontaneous abortion (before 22 weeks of gestation) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.66 [1.37;2.01] -/-   -/983,258 - -
ref
S11264
R41405		 Yaris, 2005 Spontaneous abortions during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 0.47 [0.03;8.37] C 0/27   9/248 9 27
ref
Total 3 studies 1.65 [1.37;2.00] 24 31
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ozturk, 2016Ozturk, 2016 2.26[0.11; 45.78]1540%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate Kjaersgaard, 2013Kjaersgaard, 2013 1.66[1.37; 2.01]--99%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Yaris, 2005Yaris, 2005 0.47[0.03; 8.37]9270%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Total (3 studies) I2 = 0% 1.65[1.37; 2.00]24310.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.65[1.37; 2.00]24310%NAOzturk, 2016 Kjaersgaard, 2013 Yaris, 2005 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.65[1.37; 2.00]24310%NAOzturk, 2016 Kjaersgaard, 2013 Yaris, 2005 3 Tags Adjustment   - No  - No 1.65[1.37; 2.00]24310%NAOzturk, 2016 Kjaersgaard, 2013 Yaris, 2005 3 Monotherapy   - no or not specified  - no or not specified 1.65[1.37; 2.00]24310%NAOzturk, 2016 Kjaersgaard, 2013 Yaris, 2005 3 All studiesAll studies 1.65[1.37; 2.00]24310%NAOzturk, 2016 Kjaersgaard, 2013 Yaris, 2005 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.65[1.37; 2.00]24310%NAOzturk, 2016 Kjaersgaard, 2013 Yaris, 2005 30.510.01.0