Amitriptyline updated on 07-01-2025

Preeclampsia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11106
R41054		 Palmsten a (control exposed to SSRIs), 2013 Preeclampsia and/or eclampsia (ICD-9 codes 642.4x–642.7x, after 140 gestational days and within 30 days after the delivery) 2nd and/or 3rd trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 2.25 [1.54;3.28] C
excluded (control group) 		31/271   1,033/19,000 1,064 271
ref
S11107
R41056		 Palmsten a (Controls unexposed, sick), 2013 Preeclampsia and/or eclampsia (ICD-9 codes 642.4x–642.7x, after 140 gestational days and within 30 days after the delivery) 2nd and/or 3rd trimester retrospective cohort (claims database) unexposed, sick Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) Unexposed sick: recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 1.72 [1.24;2.40] 31/271   3,215/59,219 3,246 271
ref
Total 1 studies 1.72 [1.24;2.39] 3,246 271
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Palmsten a (Controls unexposed, sick), 2013Palmsten a, 2013 1 1.72[1.24; 2.40]3,2462710%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.72[1.24; 2.39]3,246271 -NAPalmsten a (Controls unexposed, sick), 2013 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.72[1.24; 2.39]3,246271 -NAPalmsten a (Controls unexposed, sick), 2013 1 Tags Adjustment   - Yes  - Yes 1.72[1.24; 2.39]3,246271 -NAPalmsten a (Controls unexposed, sick), 2013 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.72[1.24; 2.39]3,246271 -NAPalmsten a (Controls unexposed, sick), 2013 1 Unexposed sick   - recent illness/treatment (during o ...  - recent illness/treatment (during or juste before pregnancy or treatment stopped in view of pregnancy) 1.72[1.24; 2.39]3,246271 -NAPalmsten a (Controls unexposed, sick), 2013 1 All studiesAll studies 1.72[1.24; 2.39]3,246271 -NAPalmsten a (Controls unexposed, sick), 2013 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 11106

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.72[1.24; 2.39]3,246271 -NAPalmsten a (Controls unexposed, sick), 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.25[1.54; 3.28]1,064271 -NAPalmsten a (control exposed to SSRIs), 2013 10.510.01.0