Clomipramine updated on 07-01-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11598
R42501		 Ozturk, 2016 Miscarriages at least 1st trimester prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 17.00 [0.33;887.88] C 1/1   15/261 16 1
ref
S11206
R41259		 Kjaersgaard (Controls unexposed, NOS), 2013 Spontaneous abortion (before 22 weeks of gestation) during pregnancy (anytime or not specified) population based cohort retrospective unexposed (general population or NOS) excluded Adjustment: No Monotherapy: no or not specified 1.50 [0.99;2.27]
excluded (control group) 		-/-   -/983,258 - -
ref
S11207
R41260		 Kjaersgaard (Controls unexposed, sick), 2013 Spontaneous abortion (before 22 weeks of gestation) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: No Monotherapy: no or not specified Unexposed sick: intermediate history of illness/treatment (3-12 months before pregnancy) 1.77 [0.80;3.96] -/-   -/- - -
ref
S11263
R41404		 Yaris, 2005 Spontaneous abortions during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.00 [0.06;18.25] C 0/13   9/248 9 13
ref
Total 3 studies 1.85 [0.87;3.94] 25 14
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ozturk, 2016Ozturk, 2016 17.00[0.33; 887.88]1614%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Kjaersgaard (Controls unexposed, sick), 2013Kjaersgaard, 2013 1 1.77[0.80; 3.96]--90%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Yaris, 2005Yaris, 2005 1.00[0.06; 18.25]9137%ROB confusion: criticalROB selection: unclearROB classification: moderateROB missing: unclearROB mesure: unclearROB reporting: moderate Total (3 studies) I2 = 0% 1.85[0.87; 3.94]25140.550.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.85[0.87; 3.94]25140%NAOzturk, 2016 Kjaersgaard (Controls unexposed, sick), 2013 Yaris, 2005 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.96[0.20; 43.83]251422%NAOzturk, 2016 Yaris, 2005 2 unexposed, sickunexposed, sick 1.77[0.80; 3.94]-- -NAKjaersgaard (Controls unexposed, sick), 2013 1 Tags Adjustment   - No  - No 1.85[0.87; 3.94]25140%NAOzturk, 2016 Kjaersgaard (Controls unexposed, sick), 2013 Yaris, 2005 3 Monotherapy   - no or not specified  - no or not specified 1.85[0.87; 3.94]25140%NAOzturk, 2016 Kjaersgaard (Controls unexposed, sick), 2013 Yaris, 2005 3 Unexposed sick   - intermediate history of illness/tre ...  - intermediate history of illness/treatment (3-12 months before pregnancy) 1.77[0.80; 3.94]-- -NAKjaersgaard (Controls unexposed, sick), 2013 1 All studiesAll studies 1.85[0.87; 3.94]25140%NAOzturk, 2016 Kjaersgaard (Controls unexposed, sick), 2013 Yaris, 2005 30.550.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 11206

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.53[1.01; 2.30]25140%NAOzturk, 2016 Kjaersgaard (Controls unexposed, NOS), 2013 Yaris, 2005 3 unexposed, sick controlsunexposed, sick controls 1.77[0.80; 3.94]-- -NAKjaersgaard (Controls unexposed, sick), 2013 10.510.01.0