Clomipramine updated on 07-01-2025

Congenital heart defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11669
R42789		 Källen, 2013 Any cardiac defect early pregnancy population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 1.49 [1.03;2.15] 28/1,399   -/- - 1,399
ref
Total 1 studies 1.49 [1.03;2.15] 0 1,399
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Källen, 2013Källen, 2013 1.49[1.03; 2.15]-1,3990%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: criticalROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.49[1.03; 2.15]-1,399 -NAKällen, 2013 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.49[1.03; 2.15]-1,399 -NAKällen, 2013 1 Tags Adjustment   - Yes  - Yes 1.49[1.03; 2.15]-1,399 -NAKällen, 2013 1 Monotherapy   - no or not specified  - no or not specified 1.49[1.03; 2.15]-1,399 -NAKällen, 2013 1 All studiesAll studies 1.49[1.03; 2.15]-1,399 -NAKällen, 2013 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.49[1.03; 2.15]191,399 -NAKällen, 2013 10.510.01.0