Clomipramine updated on 07-01-2025

Major congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S11189
R41235		 Anderson, 2020 Major birth defects 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: TCA only 1.12 [0.05;27.60] C 1/1   30,629/42,107 30,630 1
ref
S11669
R42788		 Källen, 2013 Relatively severe malformations early pregnancy population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: no or not specified 1.20 [0.94;1.53] 69/1,399   -/- - 1,399
ref
Total 2 studies 1.20 [0.94;1.53] 30,630 1,400
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.12[0.05; 27.60]30,63011%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Källen, 2013Källen, 2013 1.20[0.94; 1.53]-1,39999%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 1.20[0.94; 1.53]30,6301,4000.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.20[0.94; 1.53]-1,399 -NAKällen, 2013 1 case control studiescase control studies 1.12[0.05; 27.60]30,6301 -NAAnderson, 2020 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.20[0.94; 1.53]30,6301,4000%NAAnderson, 2020 Källen, 2013 2 Tags Adjustment   - No  - No 1.12[0.05; 27.60]30,6301 -NAAnderson, 2020 1   - Yes  - Yes 1.20[0.94; 1.53]-1,399 -NAKällen, 2013 1 Monotherapy   - no or not specified  - no or not specified 1.20[0.94; 1.53]-1,399 -NAKällen, 2013 1   - TCA only  - TCA only 1.12[0.05; 27.60]30,6301 -NAAnderson, 2020 1 All studiesAll studies 1.20[0.94; 1.53]30,6301,4000%NAAnderson, 2020 Källen, 2013 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.20[0.94; 1.53]30,6901,4000%NAAnderson, 2020 Källen, 2013 20.510.01.0