Carbamazepine (All indications)

Large for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9602
R34031		 Aydin (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2020 Large for gestational age (birth weight) throughout pregnancy retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.13 [0.00;3.60] C
excluded (control group) 		0/15   1/7 1 15
ref
S9603
R34041		 Aydin (Carbamazepine) (Controls unexposed, sick), 2020 Large for gestational age (birth weight) throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 1.48 [0.03;79.05] C 0/15   0/22 0 15
ref
S9598
R34001		 Artama (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2013 Large for gestational age (weight) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 3.21 [0.77;13.43] C
excluded (control group) 		39/1,077   2/173 41 1,077
ref
S9599
R34013		 Artama (Carbamazepine) (Controls unexposed, disease free), 2013 Large for gestational age (weight) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 1.15 [0.83;1.58]
excluded (control group) 		39/1,077   21,574/719,509 21,613 1,077
ref
S9600
R34025		 Artama (Carbamazepine) (Controls unexposed, sick), 2013 Large for gestational age (weight) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 0.88 [0.59;1.32] 39/1,077   71/1,793 110 1,077
ref
Total 2 studies 0.88 [0.59;1.32] 110 1,092
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Aydin (Carbamazepine) (Controls unexposed, sick), 2020Aydin, 2020 1 1.48[0.03; 79.05]0151%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Artama (Carbamazepine) (Controls unexposed, sick), 2013Artama, 2013 2 0.88[0.59; 1.32]1101,07799%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.88[0.59; 1.32]1101,0920.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Carbamazepine) (Controls unexposed, sick; 2: Carbamazepine) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.88[0.59; 1.32]1101,0920%NAAydin (Carbamazepine) (Controls unexposed, sick), 2020 Artama (Carbamazepine) (Controls unexposed, sick), 2013 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.88[0.59; 1.32]1101,0920%NAAydin (Carbamazepine) (Controls unexposed, sick), 2020 Artama (Carbamazepine) (Controls unexposed, sick), 2013 2 Tags Adjustment   - No  - No 1.48[0.03; 79.05]-15 -NAAydin (Carbamazepine) (Controls unexposed, sick), 2020 1   - Yes  - Yes 0.88[0.59; 1.32]1101,077 -NAArtama (Carbamazepine) (Controls unexposed, sick), 2013 1 All studiesAll studies 0.88[0.59; 1.32]1101,0920%NAAydin (Carbamazepine) (Controls unexposed, sick), 2020 Artama (Carbamazepine) (Controls unexposed, sick), 2013 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9598, 9599, 9602

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.15[0.83; 1.59]21,6131,077 -NAArtama (Carbamazepine) (Controls unexposed, disease free), 2013 1 unexposed, sick controlsunexposed, sick controls 0.88[0.59; 1.32]1101,0920%NAAydin (Carbamazepine) (Controls unexposed, sick), 2020 Artama (Carbamazepine) (Controls unexposed, sick), 2013 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.92[0.04; 20.19]421,09267%NAAydin (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2020 Artama (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2013 20.510.01.0