Carbamazepine (All indications)

Low birth weight (< 2500g)

id	Study   Auto Coste (Carbamazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2020Coste (Carbamazepine) (Controls unexposed, NOS) (Mixed indications), 2020Kilic (Carbamazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014Kilic (Carbamazepine) (Controls unexposed NOS) (Mixed indications), 2014Kilic (Carbamazepine) (Controls unexposed, sick) (Mixed indications), 2014Artama (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2013Artama (Carbamazepine) (Controls unexposed, disease free), 2013Artama (Carbamazepine) (Controls unexposed, sick), 2013Veiby (Carbamazepine) (Controls exposed to Lamotrigine, sick) b, 2013Veiby (Carbamazepine) (Controls unexposed, disease free) b, 2013Veiby (Carbamazepine) (Controls unexposed, sick) b, 2013Kini (Carbamazepine) (Controls unexposed, sick), 2006	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S9776 R34958	Coste (Carbamazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2020	Weight at birth <2500 g	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: No	1.15 [0.79;1.67] C excluded (control group)	35/502   179/2,916	214	502		ref
S9777 R34976	Coste (Carbamazepine) (Controls unexposed, NOS) (Mixed indications), 2020	Weight at birth <2500 g	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No	1.26 [0.87;1.81] C	31/468   91,172/1,707,707	91,203	468		ref
S9772 R34943	Kilic (Carbamazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014	Low birth weight (< 2500 g)	during pregnancy (anytime or not specified)	population based cohort retrospective	exposed to other treatment, sick excluded	Adjustment: No	1.22 [0.73;2.05] C excluded (control group)	23/347   48/876	71	347		ref
S9773 R34946	Kilic (Carbamazepine) (Controls unexposed NOS) (Mixed indications), 2014	Low birth weight (< 2500 g)	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed (general population or NOS) excluded	Adjustment: Yes	1.80 [1.20;2.70] excluded (control group)	23/347   23,503/673,844	23,526	347		ref
S9774 R34949	Kilic (Carbamazepine) (Controls unexposed, sick) (Mixed indications), 2014	Low birth weight (< 2500 g)	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed, sick	Adjustment: No Controls: epilepsy indication	1.43 [0.92;2.23] C	23/347   249/5,275	272	347		ref
S9598 R33999	Artama (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2013	Low birth weight (< 2500g)	during pregnancy (anytime or not specified)	population based cohort retrospective	exposed to other treatment, sick excluded	Adjustment: No	1.38 [0.58;3.27] C excluded (control group)	51/1,077   6/173	57	1,077		ref
S9599 R34011	Artama (Carbamazepine) (Controls unexposed, disease free), 2013	Low birth weight (< 2500g)	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed, disease free excluded	Adjustment: Yes	1.63 [1.23;2.17] excluded (control group)	51/1,077   21,546/719,509	21,597	1,077		ref
S9600 R34023	Artama (Carbamazepine) (Controls unexposed, sick), 2013	Low birth weight (< 2500g)	during pregnancy (anytime or not specified)	population based cohort retrospective	unexposed, sick	Adjustment: Yes	1.31 [0.89;1.92]	51/1,077   65/1,793	116	1,077		ref
S9743 R34761	Veiby (Carbamazepine) (Controls exposed to Lamotrigine, sick) b, 2013	Low birth weight (< 2500 grams)	during pregnancy (anytime or not specified)	prospective cohort	exposed to other treatment, sick excluded	Adjustment: No	1.30 [0.38;4.46] C excluded (control group)	5/67   6/103	11	67		ref
S9745 R34780	Veiby (Carbamazepine) (Controls unexposed, disease free) b, 2013	Low birth weight (< 2500 grams)	during pregnancy (anytime or not specified)	prospective cohort	unexposed, disease free excluded	Adjustment: Yes	1.80 [0.70;4.40] excluded (control group)	5/67   5,024/106,899	5,029	67		ref
S9746 R34794	Veiby (Carbamazepine) (Controls unexposed, sick) b, 2013	Low birth weight (< 2500 grams)	during pregnancy (anytime or not specified)	prospective cohort	unexposed, sick	Adjustment: No	1.86 [0.66;5.27] C	5/67   16/386	21	67		ref
S9669 R34418	Kini (Carbamazepine) (Controls unexposed, sick), 2006	Birth weight <2500 g	during pregnancy (anytime or not specified)	retrospective cohort	unexposed, sick	Adjustment: No	0.27 [0.07;1.00] C	3/94   11/101	14	94		ref
					Total	5 studies	1.26 [0.93;1.70]		91,626	2,053
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 9598, 9599, 9743, 9745, 9772, 9773, 9776