Carbamazepine (All indications) - Medication and Pregnancy KB

Carbamazepine (All indications)

Very preterm (28 to 32 weeks)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S9776 R34954	Coste (Carbamazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2020	Gestational age at birth (< 32 WA)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: No	1.59 [0.44;5.71] ^C excluded (control group)	3/502 11/2,916	14	502		ref
S9777 R34972	Coste (Carbamazepine) (Controls unexposed, NOS) (Mixed indications), 2020	Gestational age at birth (27–31 WA)	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: No	1.28 [0.41;3.99] ^C	3/468 8,556/1,707,707	8,559	468		ref
					Total	1 studies	1.28 [0.41;3.99]		8,559	468
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Carbamazepine) (Controls unexposed, NOS) (Mixed indications;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9776