Carbamazepine (All indications)

Digestive system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S12856
R48497		 Thomas (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2021 Gastro-intestinal malformations 1st trimester prospective cohort exposed to other treatment, sick excluded Adjustment: No 0.10 [0.00;5.15] C
excluded (control group) 		0/490   0/50 0 490
ref
S12858
R48509		 Thomas (Carbamazepine) (Controls unexposed, sick), 2021 Gastro-intestinal malformations 1st trimester prospective cohort unexposed, sick Adjustment: No 0.23 [0.01;5.68] C 0/490   1/340 1 490
ref
S9655
R34369		 Campbell (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2014 Gastrointestinal tract defect 1st trimester prospective cohort exposed to other treatment, sick Adjustment: No 0.79 [0.26;2.42] C 5/1,657   8/2,098 13 1,657
ref
S9643
R34308		 Veiby (Carbamazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014 Digestive throughout pregnancy population based cohort retrospective exposed to other treatment, sick Adjustment: No 0.91 [0.20;4.09] C 3/685   4/833 7 685
ref
Total 3 studies 0.76 [0.32;1.80] 21 2,832
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Thomas (Carbamazepine) (Controls unexposed, sick), 2021Thomas, 2021 1 0.23[0.01; 5.68]14907%ROB confusion: seriousROB selection: moderateROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Campbell (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2014Campbell, 2014 2 0.79[0.26; 2.42]131,65760%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Veiby (Carbamazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014Veiby, 2014 3 0.91[0.20; 4.09]768533%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: moderateROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 0.76[0.32; 1.80]212,8320.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Carbamazepine) (Controls unexposed, sick; 2: Carbamazepine) (Controls exposed to Lamotrigine, sick; 3: Carbamazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.76[0.32; 1.80]212,8320%NAThomas (Carbamazepine) (Controls unexposed, sick), 2021 Campbell (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2014 Veiby (Carbamazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.23[0.01; 5.68]1490 -NAThomas (Carbamazepine) (Controls unexposed, sick), 2021 1 exposed to other treatment, sickexposed to other treatment, sick 0.83[0.34; 2.04]202,3420%NACampbell (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2014 Veiby (Carbamazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014 2 Tags Adjustment   - No  - No 0.76[0.32; 1.80]212,8320%NAThomas (Carbamazepine) (Controls unexposed, sick), 2021 Campbell (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2014 Veiby (Carbamazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014 3 All studiesAll studies 0.76[0.32; 1.80]212,8320%NAThomas (Carbamazepine) (Controls unexposed, sick), 2021 Campbell (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2014 Veiby (Carbamazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014 30.110.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 12856

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls Out of scale0.23[0.01; 5.68]1490 -NAThomas (Carbamazepine) (Controls unexposed, sick), 2021 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.75[0.31; 1.80]202,8320%NAThomas (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2021 Campbell (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2014 Veiby (Carbamazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2014 30.510.01.0