Carbamazepine (All indications)

Emotional disorders

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S15231
R62548		 Dreier (Carbamazepine) (Epilepsy) (Controls exposed to LTG), 2023 Mood disorder - Corresponding ICD-10 F-chapter - Up to 22 years of age during pregnancy (anytime or not specified) population based cohort propective exposed to other treatment, sick excluded Adjustment: No 7.84 [3.91;15.73] C
excluded (control group) 		39/2,665   10/5,288 49 2,665
ref
S15235
R62603		 Dreier (Carbamazepine) (Epilepsy) (Controls unexposed, sick), 2023 Mood disorder - Corresponding ICD-10 F-chapter - Up to 22 years of age during pregnancy (anytime or not specified) population based cohort propective unexposed, sick Adjustment: Yes 1.03 [0.61;1.74] 39/2,665   58/22,203 97 2,665
ref
S9723
R34620		 Huber-Mollema (Carbamazepine), 2019 Internalizing problems (The Child Behavior Checklist) (Completed by mothers) Clinical cutoff throughout pregnancy prospective cohort exposed to other treatment, sick Adjustment: No 0.62 [0.24;1.60] C 7/37   24/88 31 37
ref
S9711
R34567		 Cohen (Carbamazepine), 2013 Anxiety in mean (BASC scale) (Parent ratings) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick Adjustment: Yes extrapolated (cont. endpoint) 0.84 [0.43;1.65] -/52   -/61 - 52
ref
Total 3 studies 0.89 [0.61;1.30] 128 2,754
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Dreier (Carbamazepine) (Epilepsy) (Controls unexposed, sick), 2023Dreier, 2023 1 1.03[0.61; 1.74]972,66552%ROB confusion: seriousROB selection: lowROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Huber-Mollema (Carbamazepine), 2019Huber-Mollema, 2019 2 0.62[0.24; 1.60]313716%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate Cohen (Carbamazepine), 2013Cohen, 2013 3 0.84[0.43; 1.65]-5232%ROB confusion: moderateROB selection: lowROB classification: lowROB missing: criticalROB mesure: lowROB reporting: low Total (3 studies) I2 = 0% 0.89[0.61; 1.30]1282,7540.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Carbamazepine) (Epilepsy) (Controls unexposed, sick; 2: Carbamazepine; 3: Carbamazepine;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.89[0.61; 1.30]1282,7540%NADreier (Carbamazepine) (Epilepsy) (Controls unexposed, sick), 2023 Huber-Mollema (Carbamazepine), 2019 Cohen (Carbamazepine), 2013 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.03[0.61; 1.74]972,665 -NADreier (Carbamazepine) (Epilepsy) (Controls unexposed, sick), 2023 1 exposed to other treatment, sickexposed to other treatment, sick 0.76[0.44; 1.31]31890%NAHuber-Mollema (Carbamazepine), 2019 Cohen (Carbamazepine), 2013 2 Tags Adjustment   - No  - No 0.62[0.24; 1.60]3137 -NAHuber-Mollema (Carbamazepine), 2019 1   - Yes  - Yes 0.95[0.63; 1.44]972,7170%NADreier (Carbamazepine) (Epilepsy) (Controls unexposed, sick), 2023 Cohen (Carbamazepine), 2013 2 extrapolated (cont. endpoint)extrapolated (cont. endpoint) 0.84[0.43; 1.65]-52 -NACohen (Carbamazepine), 2013 1 All studiesAll studies 0.89[0.61; 1.30]1282,7540%NADreier (Carbamazepine) (Epilepsy) (Controls unexposed, sick), 2023 Huber-Mollema (Carbamazepine), 2019 Cohen (Carbamazepine), 2013 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 15231

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.03[0.61; 1.74]972,665 -NADreier (Carbamazepine) (Epilepsy) (Controls unexposed, sick), 2023 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.62[0.32; 8.15]802,75493%NADreier (Carbamazepine) (Epilepsy) (Controls exposed to LTG), 2023 Huber-Mollema (Carbamazepine), 2019 Cohen (Carbamazepine), 2013 30.510.01.0