Carbamazepine (All indications)

Cerebral palsy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9740
R34698		 Van der Pol (Carbamazepine) (Controls unexposed, disease free), 1991 Abnormal neurologic examination (neurologic handicap) throughout pregnancy prospective cohort unexposed, disease free excluded Adjustment: No Matched 5.40 [0.31;93.62] C
excluded (control group) 		1/11   1/55 2 11
ref
S9741
R34723		 Van der Pol (Carbamazepine) (Controls unexposed, sick), 1991 Abnormal neurologic examination (neurologic handicap) throughout pregnancy prospective cohort unexposed, sick Adjustment: No 6.79 [0.25;182.34] C 1/11   0/22 1 11
ref
Total 1 studies 6.79 [0.25;182.34] 1 11
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Van der Pol (Carbamazepine) (Controls unexposed, sick), 1991Van der Pol, 1991 1 6.79[0.25; 182.34]1110%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Carbamazepine) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 6.79[0.25; 182.34]111 -NAVan der Pol (Carbamazepine) (Controls unexposed, sick), 1991 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 6.79[0.25; 182.34]111 -NAVan der Pol (Carbamazepine) (Controls unexposed, sick), 1991 1 Tags Adjustment   - No  - No 6.79[0.25; 182.34]111 -NAVan der Pol (Carbamazepine) (Controls unexposed, sick), 1991 1 All studiesAll studies 6.79[0.25; 182.34]111 -NAVan der Pol (Carbamazepine) (Controls unexposed, sick), 1991 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9740

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 5.40[0.31; 93.62]211 -NAVan der Pol (Carbamazepine) (Controls unexposed, disease free), 1991 1 unexposed, sick controlsunexposed, sick controls 6.79[0.25; 182.34]111 -NAVan der Pol (Carbamazepine) (Controls unexposed, sick), 1991 10.510.01.0