Carbamazepine (All indications)

Feeding difficulty

id	Study   Auto Burja (Carbamazepine) (Controls unexposed, disease free), 2006Burja (Carbamazepine) (Controls unexposed, sick), 2006Yerby (Carbamazepine), 1992D'Souza (Carbamazepine) (Controls unexposed, disease free), 1991D'Souza (Carbamazepine) (Controls unexposed, sick), 1991	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S9606 R34058	Burja (Carbamazepine) (Controls unexposed, disease free), 2006	Feeding problems	during pregnancy (anytime or not specified)	retrospective cohort (registry)	unexposed, disease free excluded	Adjustment: No	1.62 [0.19;13.90] C excluded (control group)	1/19   7/211	8	19		ref
S9607 R34063	Burja (Carbamazepine) (Controls unexposed, sick), 2006	Feeding problems	during pregnancy (anytime or not specified)	retrospective cohort (registry)	unexposed, sick	Adjustment: No	1.72 [0.10;29.24] C	1/19   1/32	2	19		ref
S9683 R34465	Yerby (Carbamazepine), 1992	Feeding difficulties	during pregnancy (anytime or not specified)	prospective cohort	unexposed, disease free	Adjustment: No	0.80 [0.03;20.60] C	0/19   1/46	1	19		ref
S9612 R34100	D'Souza (Carbamazepine) (Controls unexposed, disease free), 1991	Feeding difficulty (tube fed)	throughout pregnancy	prospective cohort	unexposed, disease free excluded	Adjustment: No Matched	24.60 [0.40;1512.72] C excluded (control group)	0/3   0/62	0	3		ref
S9613 R34129	D'Souza (Carbamazepine) (Controls unexposed, sick), 1991	Feeding difficulty (tube fed)	throughout pregnancy	prospective cohort	unexposed, sick	Adjustment: No	3.00 [0.05;194.76] C	0/3   0/8	0	3		ref
					Total	3 studies	1.49 [0.22;9.94]		3	41
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 9612, 9606