Carbamazepine (All indications)

Ano-rectal atresia and stenosis

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10176
R37262		 Blotière (Carbamazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2019 Anorectal atresia 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 1.95 [0.08;47.99] C
excluded (control group) 		0/512   1/2,997 1 512
ref
S9766
R34912		 Blotière (Carbamazepine) (Controls unexposed NOS) (Mixed indications), 2019 Anorectal atresia 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 3.37 [0.21;53.97] C 0/512   544/1,875,733 544 512
ref
S9740
R34719		 Van der Pol (Carbamazepine) (Controls unexposed, disease free), 1991 Abnormal anus throughout pregnancy prospective cohort unexposed, disease free excluded Adjustment: No Matched 5.19 [0.10;276.47] C
excluded (control group) 		0/11   0/55 0 11
ref
S9741
R34744		 Van der Pol (Carbamazepine) (Controls unexposed, sick), 1991 Abnormal anus throughout pregnancy prospective cohort unexposed, sick Adjustment: No 0.65 [0.02;17.40] C 0/11   1/22 1 11
ref
Total 2 studies 1.70 [0.20;14.15] 545 523
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Blotière (Carbamazepine) (Controls unexposed NOS) (Mixed indications), 2019Blotière, 2019 1 3.37[0.21; 53.97]54451258%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Van der Pol (Carbamazepine) (Controls unexposed, sick), 1991Van der Pol, 1991 2 0.65[0.02; 17.40]11142%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.70[0.20; 14.15]5455230.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Carbamazepine) (Controls unexposed NOS) (Mixed indications; 2: Carbamazepine) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.70[0.20; 14.15]5455230%NABlotière (Carbamazepine) (Controls unexposed NOS) (Mixed indications), 2019 Van der Pol (Carbamazepine) (Controls unexposed, sick), 1991 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.37[0.21; 53.97]544512 -NABlotière (Carbamazepine) (Controls unexposed NOS) (Mixed indications), 2019 1 unexposed, sickunexposed, sick 0.65[0.02; 17.40]111 -NAVan der Pol (Carbamazepine) (Controls unexposed, sick), 1991 1 Tags Adjustment   - No  - No 1.70[0.20; 14.15]5455230%NABlotière (Carbamazepine) (Controls unexposed NOS) (Mixed indications), 2019 Van der Pol (Carbamazepine) (Controls unexposed, sick), 1991 2 All studiesAll studies 1.70[0.20; 14.15]5455230%NABlotière (Carbamazepine) (Controls unexposed NOS) (Mixed indications), 2019 Van der Pol (Carbamazepine) (Controls unexposed, sick), 1991 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9740, 10176

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.88[0.40; 37.74]5445230%NABlotière (Carbamazepine) (Controls unexposed NOS) (Mixed indications), 2019 Van der Pol (Carbamazepine) (Controls unexposed, disease free), 1991 2 unexposed, sick controlsunexposed, sick controls 0.65[0.02; 17.40]111 -NAVan der Pol (Carbamazepine) (Controls unexposed, sick), 1991 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.95[0.08; 47.99]1512 -NABlotière (Carbamazepine) (Controls exposed to Lamotrigine, sick) (Mixed indications), 2019 10.510.01.0