Carbamazepine (All indications)

Down syndrom / Trisomy 21

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9612
R34099		 D'Souza (Carbamazepine) (Controls unexposed, disease free), 1991 Down's syndrome throughout pregnancy prospective cohort unexposed, disease free excluded Adjustment: No Matched 24.60 [0.40;1512.72] C
excluded (control group) 		0/3   0/62 0 3
ref
S9613
R34128		 D'Souza (Carbamazepine) (Controls unexposed, sick), 1991 Down's syndrome throughout pregnancy prospective cohort unexposed, sick Adjustment: No 3.00 [0.05;194.76] C 0/3   0/8 0 3
ref
Total 1 studies 3.00 [0.05;194.76] 0 3
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF D'Souza (Carbamazepine) (Controls unexposed, sick), 1991D'Souza, 1991 1 3.00[0.05; 194.76]030%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Carbamazepine) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.00[0.05; 194.76]-3 -NAD'Souza (Carbamazepine) (Controls unexposed, sick), 1991 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 3.00[0.05; 194.76]-3 -NAD'Souza (Carbamazepine) (Controls unexposed, sick), 1991 1 Tags Adjustment   - No  - No 3.00[0.05; 194.76]-3 -NAD'Souza (Carbamazepine) (Controls unexposed, sick), 1991 1 All studiesAll studies 3.00[0.05; 194.76]-3 -NAD'Souza (Carbamazepine) (Controls unexposed, sick), 1991 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9612

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale24.60[0.40; 1512.72]-3 -NAD'Souza (Carbamazepine) (Controls unexposed, disease free), 1991 1 unexposed, sick controlsunexposed, sick controls 3.00[0.05; 194.76]-3 -NAD'Souza (Carbamazepine) (Controls unexposed, sick), 1991 10.510.01.0