Carbamazepine (All indications)

Assisted deliveries (forceps, vacuum, ...)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9751
R34818		 Borthen (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2010 Operative vaginal delivery (including vaginal breech delivery, forceps and vacuum delivery) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.76 [0.46;1.25] C
excluded (control group) 		39/388   30/233 69 388
ref
S9753
R34826		 Borthen (Carbamazepine) (Controls unexposed, disease free), 2010 Operative vaginal delivery (including vaginal breech delivery, forceps and vacuum delivery) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 1.10 [0.80;1.60]
excluded (control group) 		39/388   28,546/362,302 28,585 388
ref
S9755
R34834		 Borthen (Carbamazepine) (Controls unexposed, sick), 2010 Operative vaginal delivery (including vaginal breech delivery, forceps and vacuum delivery) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: No 1.23 [0.85;1.78] C 39/388   155/1,863 194 388
ref
S9615
R34165		 Endo (Carbamazepine) (Controls unexposed, disease free), 2004 Forceps deliveries throughout pregnancy retrospective cohort unexposed, disease free excluded Adjustment: No 0.75 [0.04;13.33] C
excluded (control group) 		0/8   53/656 53 8
ref
S9616
R34180		 Endo (Carbamazepine) (Controls unexposed, sick), 2004 Forceps deliveries throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 0.07 [0.00;8.55] C 0/8   0/1 0 8
ref
Total 2 studies 0.82 [0.11;5.98] 194 396
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Borthen (Carbamazepine) (Controls unexposed, sick), 2010Borthen, 2010 1 1.23[0.85; 1.78]19438886%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Endo (Carbamazepine) (Controls unexposed, sick), 2004Endo, 2004 2 0.07[0.00; 8.55]0814%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 27% 0.82[0.11; 5.98]1943960.05.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Carbamazepine) (Controls unexposed, sick; 2: Carbamazepine) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.82[0.11; 5.98]19439627%NABorthen (Carbamazepine) (Controls unexposed, sick), 2010 Endo (Carbamazepine) (Controls unexposed, sick), 2004 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.82[0.11; 5.98]19439627%NABorthen (Carbamazepine) (Controls unexposed, sick), 2010 Endo (Carbamazepine) (Controls unexposed, sick), 2004 2 Tags Adjustment   - No  - No 0.82[0.11; 5.98]19439627%NABorthen (Carbamazepine) (Controls unexposed, sick), 2010 Endo (Carbamazepine) (Controls unexposed, sick), 2004 2 All studiesAll studies 0.82[0.11; 5.98]19439627%NABorthen (Carbamazepine) (Controls unexposed, sick), 2010 Endo (Carbamazepine) (Controls unexposed, sick), 2004 20.05.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9615, 9751, 9753

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.09[0.78; 1.54]28,6383960%NABorthen (Carbamazepine) (Controls unexposed, disease free), 2010 Endo (Carbamazepine) (Controls unexposed, disease free), 2004 2 unexposed, sick controlsunexposed, sick controls 0.82[0.11; 5.98]19439627%NABorthen (Carbamazepine) (Controls unexposed, sick), 2010 Endo (Carbamazepine) (Controls unexposed, sick), 2004 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.76[0.46; 1.25]69388 -NABorthen (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2010 10.510.01.0