Carbamazepine (All indications)

Ectopic pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9655
R34375
Campbell (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2014 Ectopic pregnancy 1st trimester prospective cohort exposed to other treatment, sick Adjustment: No 3.84 [0.16;94.34] C 1/1,718   0/2,198 1 1,718
ref
Total 1 studies 3.84 [0.16;94.34] 1 1,718
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Campbell (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2014Campbell, 2014 1 3.84[0.16; 94.34]11,7180%ROB confusion: criticalROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Carbamazepine) (Controls exposed to Lamotrigine, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 3.84[0.16; 94.34]11,718 -NACampbell (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2014 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 3.84[0.16; 94.34]11,718 -NACampbell (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2014 1 Tags Adjustment   - No  - No 3.84[0.16; 94.34]11,718 -NACampbell (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2014 1 All studiesAll studies 3.84[0.16; 94.34]11,718 -NACampbell (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2014 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 3.84[0.16; 94.34]11,718 -NACampbell (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2014 10.510.01.0