Carbamazepine (All indications) - Medication and Pregnancy KB

Carbamazepine (All indications)

Gestational diabetes

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S12674 R47885	Mari (Carbamazepine), 2022	Gestational diabetes	throughout pregnancy	retrospective cohort	exposed to other treatment, sick	Adjustment: No	0.11 [0.00;2.96] ^C	0/29 1/11	1	29		ref
S9602 R34034	Aydin (Carbamazepine) (Controls exposed to Lamotrigine, sick), 2020	Gestational diabetes mellitus	throughout pregnancy	retrospective cohort	exposed to other treatment, sick excluded	Adjustment: No	1.44 [0.05;40.54] ^C excluded (control group)	1/15 0/7	1	15		ref
S9603 R34044	Aydin (Carbamazepine) (Controls unexposed, sick), 2020	Gestational diabetes mellitus	throughout pregnancy	retrospective cohort	unexposed, sick	Adjustment: No	1.50 [0.09;26.01] ^C	1/15 1/22	2	15		ref
S9640 R34295	Pennell (Carbamazepine), 2012	Gestational Diabetes	during pregnancy (anytime or not specified)	prospective cohort	exposed to other treatment, sick	Adjustment: No	0.20 [0.02;1.76] ^C	1/92 5/97	6	92		ref
S9729 R34642	McVearry (Carbamazepine), 2009	Gestational diabetes	during pregnancy (anytime or not specified)	prospective cohort	exposed to other treatment, sick	Adjustment: No	1.13 [0.07;19.74] ^C	1/16 1/18	2	16		ref
					Total	4 studies	0.42 [0.11;1.61]		11	152
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Carbamazepine; 2: Carbamazepine) (Controls unexposed, sick; 3: Carbamazepine; 4: Carbamazepine;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Sub-groups analysis using all included studies

excluded 9602