Carbamazepine (All indications)

Childhood autism (F84.0)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9706
R34546		 Christensen (Carbamazepine) (Controls exposed to Lamotrigine, sick) (Indications NOS), 2013 Childhood autism (mean age almost 9 years old) during pregnancy (anytime or not specified) population based cohort propective exposed to other treatment, sick excluded Adjustment: No 0.84 [0.15;4.59] C
excluded (control group) 		2/386   4/647 6 386
ref
S9708
R34550		 Christensen (Carbamazepine) (Controls unexposed NOS) (Indications NOS), 2013 Childhood autism (mean age almost 9 years old) during pregnancy (anytime or not specified) population based cohort propective unexposed (general population or NOS) Adjustment: Yes 1.40 [0.40;5.80] 2/386   2,065/655,153 2,067 386
ref
Total 1 studies 1.40 [0.37;5.33] 2,067 386
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Christensen (Carbamazepine) (Controls unexposed NOS) (Indications NOS), 2013Christensen, 2013 1 1.40[0.40; 5.80]2,0673860%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Carbamazepine) (Controls unexposed NOS) (Indications NOS;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.40[0.37; 5.33]2,067386 -NAChristensen (Carbamazepine) (Controls unexposed NOS) (Indications NOS), 2013 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.40[0.37; 5.33]2,067386 -NAChristensen (Carbamazepine) (Controls unexposed NOS) (Indications NOS), 2013 1 Tags Adjustment   - Yes  - Yes 1.40[0.37; 5.33]2,067386 -NAChristensen (Carbamazepine) (Controls unexposed NOS) (Indications NOS), 2013 1 All studiesAll studies 1.40[0.37; 5.33]2,067386 -NAChristensen (Carbamazepine) (Controls unexposed NOS) (Indications NOS), 2013 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9706

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.40[0.37; 5.33]2,067386 -NAChristensen (Carbamazepine) (Controls unexposed NOS) (Indications NOS), 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.84[0.15; 4.59]6386 -NAChristensen (Carbamazepine) (Controls exposed to Lamotrigine, sick) (Indications NOS), 2013 10.510.01.0