Valproate (All indications)

Neonatal disorders (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9392
R32895		 Coste (Valproate) (Controls unexposed, NOS), 2020 Neonatal condition during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 0.91 [0.75;1.11] C 119/991   222,201/1,710,441 222,320 991
ref
S9441
R33152		 Wen (Valproate) (Mixed indications), 2017 Abnormal condition of new born during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 1.35 [0.87;2.08] C 23/226   3,407/43,956 3,430 226
ref
S9297
R32325		 D'Souza (Valproate) (Controls unexposed, disease free), 1991 Neonatal conditions throughout pregnancy prospective cohort unexposed, disease free excluded Adjustment: No Matched 10.27 [0.19;570.25] C
excluded (control group) 		1/1   6/62 7 1
ref
S9298
R32354		 D'Souza (Valproate) (Controls unexposed, sick), 1991 Neonatal conditions throughout pregnancy prospective cohort unexposed, sick Adjustment: No 4.33 [0.06;320.42] C 1/1   2/8 3 1
ref
Total 3 studies 1.05 [0.76;1.44] 225,753 1,218
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Coste (Valproate) (Controls unexposed, NOS), 2020Coste, 2020 1 0.91[0.75; 1.11]222,32099166%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Wen (Valproate) (Mixed indications), 2017Wen, 2017 2 1.35[0.87; 2.08]3,43022633%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA D'Souza (Valproate) (Controls unexposed, sick), 1991D'Souza, 1991 3 4.33[0.06; 320.42]311%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 35% 1.05[0.76; 1.44]225,7531,2180.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate) (Controls unexposed, NOS; 2: Valproate) (Mixed indications; 3: Valproate) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.05[0.76; 1.44]225,7531,21835%NACoste (Valproate) (Controls unexposed, NOS), 2020 Wen (Valproate) (Mixed indications), 2017 D'Souza (Valproate) (Controls unexposed, sick), 1991 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.06[0.73; 1.53]225,7501,21761%NACoste (Valproate) (Controls unexposed, NOS), 2020 Wen (Valproate) (Mixed indications), 2017 2 unexposed, sickunexposed, sick 4.33[0.06; 320.42]31 -NAD'Souza (Valproate) (Controls unexposed, sick), 1991 1 Tags Adjustment   - No  - No 1.05[0.76; 1.44]225,7531,21835%NACoste (Valproate) (Controls unexposed, NOS), 2020 Wen (Valproate) (Mixed indications), 2017 D'Souza (Valproate) (Controls unexposed, sick), 1991 3 All studiesAll studies 1.05[0.76; 1.44]225,7531,21835%NACoste (Valproate) (Controls unexposed, NOS), 2020 Wen (Valproate) (Mixed indications), 2017 D'Souza (Valproate) (Controls unexposed, sick), 1991 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9297

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.08[0.73; 1.60]225,7571,21849%NACoste (Valproate) (Controls unexposed, NOS), 2020 Wen (Valproate) (Mixed indications), 2017 D'Souza (Valproate) (Controls unexposed, disease free), 1991 3 unexposed, sick controlsunexposed, sick controls 4.33[0.06; 320.42]31 -NAD'Souza (Valproate) (Controls unexposed, sick), 1991 10.510.01.0