Valproate (All indications)

Large for gestational age (weight)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S9287
R32242		 Aydin (Valproate) (Controls exposed to Lamotrigine, sick), 2020 Large for gestational age (birth weight) throughout pregnancy retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.17 [0.01;5.04] C
excluded (control group) 		0/11   1/7 1 11
ref
S9288
R32252		 Aydin (Valproate) (Controls unexposed, sick), 2020 Large for gestational age (birth weight) throughout pregnancy retrospective cohort unexposed, sick Adjustment: No 2.05 [0.04;110.56] C 0/11   0/22 0 11
ref
S9324
R32502		 Putignano (Valproate), 2019 Large for gestational age (LGA) (weight) during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: No Matched 1.79 [0.92;3.46] C 12/131   49/917 61 131
ref
S9283
R32212		 Artama (Valproate) (Controls exposed to Lamotrigine, sick), 2013 Large for gestational age (weight) during pregnancy (anytime or not specified) population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 3.28 [0.77;13.97] C
excluded (control group) 		26/703   2/173 28 703
ref
S9284
R32224		 Artama (Valproate) (Controls unexposed, disease free), 2013 Large for gestational age (weight) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 1.30 [0.88;1.93]
excluded (control group) 		26/703   21,574/719,509 21,600 703
ref
S9285
R32236		 Artama (Valproate) (Controls unexposed, sick), 2013 Large for gestational age (weight) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 0.93 [0.58;1.49] 26/703   71/1,793 97 703
ref
Total 3 studies 1.21 [0.74;1.98] 158 845
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Aydin (Valproate) (Controls unexposed, sick), 2020Aydin, 2020 1 2.05[0.04; 110.56]0111%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Putignano (Valproate), 2019Putignano, 2019 2 1.79[0.92; 3.46]6113139%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Artama (Valproate) (Controls unexposed, sick), 2013Artama, 2013 3 0.93[0.58; 1.49]9770360%ROB confusion: moderateROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 22% 1.21[0.74; 1.98]1588450.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Valproate) (Controls unexposed, sick; 2: Valproate; 3: Valproate) (Controls unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.21[0.74; 1.98]15884522%NAAydin (Valproate) (Controls unexposed, sick), 2020 Putignano (Valproate), 2019 Artama (Valproate) (Controls unexposed, sick), 2013 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.79[0.92; 3.46]61131 -NAPutignano (Valproate), 2019 1 unexposed, sickunexposed, sick 0.94[0.59; 1.50]977140%NAAydin (Valproate) (Controls unexposed, sick), 2020 Artama (Valproate) (Controls unexposed, sick), 2013 2 Tags Adjustment   - No  - No 1.79[0.94; 3.44]611420%NAAydin (Valproate) (Controls unexposed, sick), 2020 Putignano (Valproate), 2019 2   - Yes  - Yes 0.93[0.58; 1.49]97703 -NAArtama (Valproate) (Controls unexposed, sick), 2013 1 MatchedMatched 1.79[0.92; 3.46]61131 -NAPutignano (Valproate), 2019 1 All studiesAll studies 1.21[0.74; 1.98]15884522%NAAydin (Valproate) (Controls unexposed, sick), 2020 Putignano (Valproate), 2019 Artama (Valproate) (Controls unexposed, sick), 2013 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 9283, 9284, 9287

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.41[1.01; 1.98]21,6618340%NAPutignano (Valproate), 2019 Artama (Valproate) (Controls unexposed, disease free), 2013 2 unexposed, sick controlsunexposed, sick controls 0.94[0.59; 1.50]977140%NAAydin (Valproate) (Controls unexposed, sick), 2020 Artama (Valproate) (Controls unexposed, sick), 2013 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.14[0.07; 18.03]2971459%NAAydin (Valproate) (Controls exposed to Lamotrigine, sick), 2020 Artama (Valproate) (Controls exposed to Lamotrigine, sick), 2013 20.510.01.0